Urological Disorders

Up to 40% of patients hospitalized with urinary tract infection unnecessarily receive extended-spectrum antibiotics.

The approval was based on data from three phase 3 trials which compared the efficacy of different dosing regimens of pivmecillinam to placebo, to another oral antibacterial drug, and to ibuprofen.

17.4 percent reduction seen in empiric extended-spectrum days of therapy, with no increase in safety outcomes.

Although viral infection is a potential cause of painful interstitial cystitis, few previous studies have examined antiviral treatment.

The summary below gives an overview of important additions and changes MPR has made to its drug database through the end of March. The chart below provides highlights of key monograph updates made this month (not an inclusive list). Click on the name of the drugs to view the full monographs on eMPR.com. Key: D=Dosing,…

Kidneys are the most common organs needed for transplant; end-stage kidney disease rates are expected to increase from 29% to 68% in the US by 2030.

After 12 days on the transplant wait list, Gibbon received his new lungs and liver from the same donor during a 10-hour surgical procedure.

Vafseo is an oral reversible inhibitor of hypoxia-inducible factor (HIF)-prolyl-4-hydroxylases (PH)1, PH2, and PH3.

Simple risk score, including nine covariates, predicted risk for CP-AKI in monotonic manner in derivation, validation cohorts.

A 62-year-old man received a genetically modified pig kidney at Massachusetts General Hospital.

Ondansetron, a commonly prescribed antiemetic, is known to prolong the QT interval.

The table below is a review of notable updates that occurred in February 2024 for investigational products in development (not an inclusive list). Click on the status to view our full coverage.

The approval was based on data from a phase 3 trial that compared cefepime/enmetazobactam to piperacillin/tazobactam in adults with cUTI, including pyelonephritis.

Sibeprenlimab is a humanized IgG2 monoclonal antibody that reduces the production of galactose deficient IgA1 by binding to and neutralizing a proliferation-inducing ligand.

Cefepime-taniborbactam superior for composite success, which included microbiologic and clinical success

Greatest reduction in risk seen for those receiving 21 to 50 phosphodiesterase type 5 inhibitor prescriptions.

The Food and Drug Administration (FDA) has expanded the labeling for Avycaz (ceftazidime and avibactam) to include pediatric patients from birth (at least 31 weeks gestational age) to less than 3 months for the treatment of complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI) including pyelonephritis, and hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia…

Sulopenem etzadroxil/probenecid was found to be noninferior to amoxicillin/clavulanic acid (Augmentin®) in the treatment of uncomplicated urinary tract infection (uUTI) in adult women, according to data from the phase 3 REASSURE trial. Sulopenem etzadroxil is an investigational oral penem anti-infective that has been combined with probenecid in a bilayer tablet. The REASSURE trial was conducted…