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Duaklir Pressair Generic Name & Formulations
Legal Class
Rx
General Description
Aclidinium bromide 400mcg, formoterol fumarate 12mcg; per actuation; dry powder for oral inhalation.
Pharmacological Class
Anticholinergic + long-acting beta-2 agonist (LABA).
How Supplied
Dry powder inhaler—30, 60 doses
Manufacturer
Generic Availability
NO
Duaklir Pressair Indications
Indications
Maintenance treatment of COPD.
Limitations of Use
Not indicated for relief of acute bronchospasm or for treatment of asthma.
Duaklir Pressair Dosage and Administration
Adult
1 inhalation twice daily (in the AM + PM). Max 1 inhalation twice daily.
Children
Not established.
Duaklir Pressair Contraindications
Contraindications
Use of LABA without inhaled corticosteroid (ICS) in asthma. Milk protein sensitivity.
Duaklir Pressair Boxed Warnings
Not Applicable
Duaklir Pressair Warnings/Precautions
Warnings/Precautions
LABA as monotherapy (without ICS) for asthma can increase risk of asthma-related events. Do not initiate in acute deteriorating COPD. Not for relief of acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue immediately and treat if paradoxical bronchospasm or immediate hypersensitivity reactions occur; use alternative therapy. Cardiovascular disorders (eg, coronary insufficiency, cardiac arrhythmias, hypertension). Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Hypokalemia. Hyperglycemia. Narrow-angle glaucoma. Urinary retention. Prostatic hyperplasia. Bladder-neck obstruction. Pregnancy. Labor & delivery. Nursing mothers.
Duaklir Pressair Pharmacokinetics
See Literature
Duaklir Pressair Interactions
Interactions
Caution with concomitant other adrenergic drugs; may potentiate sympathetic effects. Concomitant xanthine derivatives, steroids, or diuretics may potentiate hypokalemia. Caution with non-K+-sparing diuretics. Extreme caution with MAOIs, tricyclics, or others that prolong QTc interval. Antagonized by β-blockers; if needed, use cardioselective agents if no acceptable alternatives. Additive effects with concomitant other anticholinergic-containing drugs; avoid.
Duaklir Pressair Adverse Reactions
Adverse Reactions
Upper respiratory tract infection, headache, back pain; paradoxical bronchospasm, hypersensitivity reactions, cardiovascular effects.
Duaklir Pressair Clinical Trials
See Literature
Duaklir Pressair Note
Not Applicable
Duaklir Pressair Patient Counseling
See Literature
