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Lithostat Generic Name & Formulations
Legal Class
Rx
General Description
Acetohydroxamic acid 250mg; tabs.
Pharmacological Class
Urease inhibitor.
How Supplied
Tabs—100
Manufacturer
Lithostat Indications
Indications
As adjunctive therapy in chronic urea-splitting urinary infection.
Lithostat Dosage and Administration
Adult
Initially 12mg/kg per day every 6–8hrs; max 1.5g/day. Renal impairment: serum creatinine >1.8mg/dL: take at every 12-hour intervals; max 1g/day.
Children
Initially 10mg/kg per day; monitor. Titrate doses to obtain therapeutic effects.
Lithostat Contraindications
Contraindications
Disease and physical state amenable to surgery and antimicrobials. Urine infected by non-urease producing organisms. Infections controllable by oral antimicrobials. Renal dysfunction (CrCl <20mL/min, serum creatinine >2.5mg/dL). Females with unsatisfactory method of contraception. Pregnancy (Cat.X).
Lithostat Boxed Warnings
Not Applicable
Lithostat Warnings/Precautions
Warnings/Precautions
Severe renal impairment: monitor and consider reduced dose. Monitor liver function. Preexisting thrombophlebitis or phlebothrombosis. Monitor and obtain CBCs with reticulocytes after 2 weeks of therapy and every 3 months thereafter; if reticulocytes >6%, consider reduced dose. Nursing mothers: not recommended.
Lithostat Pharmacokinetics
See Literature
Lithostat Interactions
Interactions
Rash with concomitant alcohol. Concomitant dietary iron: may reduce absorption of both acetohydroxamic acid and iron (use IM inj form, if needed).
Lithostat Adverse Reactions
Adverse Reactions
Mild headaches, tremulousness, nervousness, depression, anxiety, GI upset, hemolytic anemia, mild reticulocytosis without anemia, rash, alopecia, phlebitis, palpitations.
Lithostat Clinical Trials
See Literature
Lithostat Note
Not Applicable
Lithostat Patient Counseling
See Literature
