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Acetazolamide Injection Generic Name & Formulations
Legal Class
Rx
General Description
Acetazolamide 500mg/vial; pwd for inj after reconstitution; preservative-free.
Pharmacological Class
Carbonic anhydrase inhibitor.
How Supplied
Contact supplier.
Manufacturer
Acetazolamide Injection Indications
Indications
Edema.
Acetazolamide Injection Dosage and Administration
Adult
Give by IV inj. Edema: give 1–2 days on, 1 day off. 250mg–375mg once daily. CHF: 250–375mg once daily in the AM. Acute high altitude sickness: see literature.
Children
Not recommended.
Acetazolamide Injection Contraindications
Contraindications
Hypokalemia. Hyponatremia. Severe renal, hepatic, or adrenocortical impairment. Hyperchloremic acidosis. Cirrhosis. Chronic noncongestive angle-closure glaucoma. Sulfonamide allergy.
Acetazolamide Injection Boxed Warnings
Not Applicable
Acetazolamide Injection Warnings/Precautions
Warnings/Precautions
Respiratory impairment. Renal calcium calculi. Diabetes. Gout. Monitor blood and electrolytes. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Acetazolamide Injection Pharmacokinetics
See Literature
Acetazolamide Injection Interactions
Interactions
Inhibits renal excretion of basic drugs and promotes excretion of acidic drugs. May increase toxicity of salicylates (acidosis), folic acid antagonists. Hypokalemia with corticosteroids, potassium wasting diuretics. Monitor phenytoin, primidone, antihyperglycemics, quinidine, lithium, cyclosporine. Antagonizes methenamine.
Acetazolamide Injection Adverse Reactions
Adverse Reactions
Anorexia, drowsiness, confusion, malaise, depression, GI distress, paresthesias, tinnitus, acidosis, initial hypokalemia, hyperuricemia, transient myopia; renal calculi, nephrotoxicity, hepatic dysfunction, blood dyscrasias, rash, fever, photosensitivity (rare).
Acetazolamide Injection Clinical Trials
See Literature
Acetazolamide Injection Note
Notes
Formerly known under the brand name Diamox.
Acetazolamide Injection Patient Counseling
See Literature
