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Hydrocodone/acetaminophen Oral Solution Generic Name & Formulations
Legal Class
CII
General Description
Hydrocodone bitartrate 7.5mg, acetaminophen 325mg; per 15mL soln; contains alcohol (7%); tropical fruit punch flavor.
Pharmacological Class
Opioid + analgesic.
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
Hydrocodone is a semisynthetic narcotic analgesic and antitussive with multiple actions qualitatively similar to those of codeine. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believed to relate to the existence of opiate receptors in the central nervous system. In addition to analgesia, narcotics may produce drowsiness, changes in mood and mental clouding.
The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined. Antipyretic activity is mediated through hypothalamic heat regulating centers. Acetaminophen inhibits prostaglandin synthetase.
Hydrocodone/acetaminophen Oral Solution Indications
Indications
Moderate to moderately severe pain.
Hydrocodone/acetaminophen Oral Solution Dosage and Administration
Adult
Administer with calibrated measuring device. ≥14yrs (≥46kg): 15mL every 4–6 hours as needed; max 90mL/day.
Children
<2yrs: not recommended. Administer with calibrated measuring device. Dosing should be based on weight (0.27mL/kg). 2–3yrs (12–15kg): 3.75mL. 4–6yrs (16–22kg): 5mL. 7–9yrs (23–31kg): 7.5mL. 10–13yrs (32–45kg): 10mL. All: give every 4–6 hours as needed; max: 6 doses/day.
Hydrocodone/acetaminophen Oral Solution Contraindications
Not Applicable
Hydrocodone/acetaminophen Oral Solution Boxed Warnings
Not Applicable
Hydrocodone/acetaminophen Oral Solution Warnings/Precautions
Warnings/Precautions
Head injury. Increased intracranial pressure. Acute abdomen. Impaired renal, hepatic, thyroid, pulmonary, or adrenocortical function. Severe renal or hepatic disease: monitor liver and renal function tests periodically. GI or GU obstruction. Post-op use. Drug abusers. Elderly. Debilitated. Labor & delivery. Pregnancy (neonatal withdrawal syndrome). Nursing mothers: not recommended.
Hydrocodone/acetaminophen Oral Solution Pharmacokinetics
Elimination
Renal. Half-life: 3.8±0.3 hours (hydrocodone); 1.25–3 hours (acetaminophen).
Hydrocodone/acetaminophen Oral Solution Interactions
Interactions
Potentiation with alcohol, other CNS depressants (eg, antihistamines, antipsychotics, antianxiety drugs). May potentiate or be potentiated by MAOIs, tricyclic antidepressants.
Hydrocodone/acetaminophen Oral Solution Adverse Reactions
Adverse Reactions
CNS/respiratory/circulatory depression, hypotension, dizziness, GI upset, constipation, urinary retention, rash; hepatotoxicity (overdosage).
Hydrocodone/acetaminophen Oral Solution Clinical Trials
See Literature
Hydrocodone/acetaminophen Oral Solution Note
Notes
Formerly known under the brand name Hycet.
Hydrocodone/acetaminophen Oral Solution Patient Counseling
See Literature
