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Excedrin Migraine Generic Name & Formulations
Legal Class
OTC
General Description
Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets.
Pharmacological Class
Analgesic + salicylate.
How Supplied
Caplets—24, 100, 200
Manufacturer
Excedrin Migraine Indications
Indications
Migraine.
Excedrin Migraine Dosage and Administration
Adult
≥18yrs: 2 caplets with a glass of water; max 2 caplets/24hrs.
Children
<18yrs: consult physician.
Excedrin Migraine Contraindications
Contraindications
NSAID allergy. Varicella, vaccinia in children and teenagers.
Excedrin Migraine Boxed Warnings
Not Applicable
Excedrin Migraine Warnings/Precautions
Warnings/Precautions
Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma. Peptic ulcer. GI bleeding disorders. Liver cirrhosis. Hepatic or renal impairment. Discontinue if signs/symptoms of GI bleed, migraine is not relieved or worsens after first dose, tinnitus, loss of hearing, new or unexpected symptoms develop, or severe skin reactions (eg, skin reddening, blisters, rash) occur. Headaches may worsen if used for ≥10 days per month. Elderly (≥60yrs). Pregnancy (esp. during ≥20 weeks): not recommended. Nursing mothers.
Excedrin Migraine Pharmacokinetics
See Literature
Excedrin Migraine Interactions
Interactions
May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed with ≥3 alcoholic drinks/day or concomitant other drugs containing acetaminophen, NSAIDs. Caution with diuretics, corticosteroids.
Excedrin Migraine Adverse Reactions
Adverse Reactions
GI upset/bleed, prolonged bleeding time, urticaria, anaphylaxis; overdosage: salicylism, hepatoxicity.
Excedrin Migraine Clinical Trials
See Literature
Excedrin Migraine Note
Not Applicable
Excedrin Migraine Patient Counseling
See Literature
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