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Acetaminophen Injection Generic Name & Formulations
Legal Class
Rx
General Description
Acetaminophen 10mg/mL; soln for IV infusion; preservative-free.
Pharmacological Class
Analgesic/antipyretic.
How Supplied
Contact supplier
Manufacturer
Acetaminophen Injection Indications
Indications
Management of mild to moderate pain or moderate to severe pain with adjunctive opioid analgesics. Fever.
Acetaminophen Injection Dosage and Administration
Adult
Ensure total amount of acetaminophen from all routes and all sources does not exceed max recommended dose. Give by IV infusion over 15 mins. <50kg: 15mg/kg every 6hrs (or 12.5mg/kg every 4hrs); max single dose: 15mg/kg (up to 750mg), max daily dose: 75mg/kg/24hrs (up to 3750mg). ≥50kg: 1000mg every 6hrs (or 650mg every 4hrs); max single dose: 1000mg, max daily dose: 4000mg/24hrs. Minimum dosing interval: 4hrs.
Children
Ensure total amount of acetaminophen from all routes and all sources does not exceed max recommended dose. Give by IV infusion over 15 mins; place small volume doses (up to 60mL) in syringe and administer using syringe pump. Fever only: (Neonates 0–28days): 12.5mg/kg every 6hrs; max daily dose: 50mg/kg/24hrs; (Infants 29days–2yrs): 15mg/kg every 6hrs; max daily dose: 60mg/kg/24hrs. Minimum dosing interval: 6hrs. Fever/pain: (<2yrs): not established (for pain); (≥2yrs): 15mg/kg every 6hrs (or 12.5mg/kg every 4hrs); max single dose: 15mg/kg (up to 750mg), max daily dose: 75mg/kg/24hrs (up to 3750mg). Minimum dosing interval: 4hrs.
Acetaminophen Injection Contraindications
Contraindications
Severe hepatic impairment. Severe active liver disease.
Acetaminophen Injection Boxed Warnings
Boxed Warning
Risk of medication errors. Hepatotoxicity.
Acetaminophen Injection Warnings/Precautions
Warnings/Precautions
Ensure correct prescribing, preparing, and administering to avoid dosing errors. Risk of acute liver failure (may result in liver transplant or death) associated with the use of doses higher than recommended or involving >1 acetaminophen-containing product. Hepatic impairment. Active hepatic disease. Alcoholism. Chronic malnutrition. Severe hypovolemia. Severe renal impairment (CrCl ≤30mL/min). Pregnancy. Nursing mothers.
Acetaminophen Injection Pharmacokinetics
See Literature
Acetaminophen Injection Interactions
Interactions
Caution with CYP2E1 inhibitors or inducers (eg, alcohol). Doses of 4000mg/day may increase INR, monitor warfarin frequently.
Acetaminophen Injection Adverse Reactions
Adverse Reactions
Nausea, vomiting, headache, insomnia; also children: constipation, pruritus; hepatotoxicity (with high doses), hypersensitivity (discontinue if occurs); rare: serious skin reactions (eg, AGEP, Stevens-Johnson Syndrome, toxic epidermal necrolysis).
Acetaminophen Injection Clinical Trials
See Literature
Acetaminophen Injection Note
Notes
Formerly known under the brand name Ofirmev.
Acetaminophen Injection Patient Counseling
See Literature
