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Actos Generic Name & Formulations
Legal Class
Rx
General Description
Pioglitazone (as HCl) 15mg, 30mg, 45mg; tabs.
Pharmacological Class
Thiazolidinedione.
How Supplied
Tabs—30, 90, 500
Manufacturer
Actos Indications
Indications
Adjunct to diet and exercise in type 2 diabetes, as monotherapy or in combination with metformin, insulin, or a sulfonylurea. Limitations of use: not for treating type 1 diabetes or diabetic ketoacidosis.
Actos Dosage and Administration
Adult
≥18yrs: Without CHF: initially 15mg or 30mg once daily; max 45mg once daily. With CHF (NYHA Class I or II): initially 15mg once daily. Concomitant insulin or sulfonylurea: reduce dose of these if needed. Concomitant strong CYP2C8 inhibitors: max 15mg daily.
Children
<18yrs: not recommended.
Actos Contraindications
Contraindications
NYHA Class III or IV heart failure.
Actos Boxed Warnings
Boxed Warning
Congestive heart failure.
Actos Warnings/Precautions
Warnings/Precautions
Symptomatic HF: not recommended. Monitor for signs/symptoms of CHF; discontinue or reduce dose if occurs. Hepatic disease. Monitor liver function before initiating therapy; if abnormalities detected, interrupt and assess probable cause; do not restart if ALT >3XULN with total bilirubin >2XULN. Routine monitoring LFTs during therapy without liver disease: not recommended. Active bladder cancer: not recommended. Prior history of bladder cancer: consider glycemic control benefits vs. risk of cancer recurrence. Risk of fractures (esp. females). Perform regular eye exams. Resumption of premenopausal ovulation in anovulatory patients may occur (may result in unintended pregnancy). Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended.
Actos Pharmacokinetics
See Literature
Actos Interactions
Interactions
Potentiated by CYP2C8 inhibitors (eg, gemfibrozil). Antagonized by CYP2C8 inducers (eg, rifampin) or topiramate (monitor for adequate glycemic control). Antagonizes oral contraceptives, midazolam. Monitor for heart failure with insulin.
Actos Adverse Reactions
Adverse Reactions
Upper respiratory tract infection, headache, sinusitis, pharyngitis, myalgia, edema, weight gain, hypoglycemia, dyspnea; changes in serum lipids (may be beneficial), macular edema.
Actos Clinical Trials
See Literature
Actos Note
Not Applicable
Actos Patient Counseling
See Literature
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