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Acticlate Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 75mg, 150mg+; tabs; +scored; contains sodium.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs—60
Manufacturer
Acticlate Indications
Indications
Adjunct in severe acne.
Acticlate Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours).
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (≥45kg): use Adults dose.
Acticlate Contraindications
Not Applicable
Acticlate Boxed Warnings
Not Applicable
Acticlate Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy. Nursing mothers: not recommended (during and for 5 days after the last dose).
Acticlate Pharmacokinetics
See Literature
Acticlate Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Acticlate Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, inhibition of bone growth, intracranial hypertension, C.difficile-associated diarrhea, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Acticlate Clinical Trials
See Literature
Acticlate Note
Not Applicable
Acticlate Patient Counseling
See Literature
Acticlate Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 75mg, 150mg+; tabs; +scored; contains sodium.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs—60
Manufacturer
Acticlate Indications
Indications
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Anthrax, including inhalational anthrax (postexposure). Alternative for selected infections when penicillin is contraindicated.
Acticlate Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours); if severe infections (eg, chronic UTI): 100mg every 12 hours. Streptococcal infections: treat for 10 days. Uncomplicated urethral, endocervical, rectal infection, or nongonococcal urethritis (NGU): 100mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg single dose followed by a second 300mg dose 1 hr later. Syphilis (early): 100mg twice daily for 2 weeks; if >1yr duration: treat for 4 weeks. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Anthrax: 100mg twice daily for 60 days.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose. Anthrax (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): use Adults dose.
Acticlate Contraindications
Not Applicable
Acticlate Boxed Warnings
Not Applicable
Acticlate Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy. Nursing mothers: not recommended (during and for 5 days after the last dose).
Acticlate Pharmacokinetics
See Literature
Acticlate Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Acticlate Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, inhibition of bone growth, intracranial hypertension, C.difficile-associated diarrhea, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Acticlate Clinical Trials
See Literature
Acticlate Note
Not Applicable
Acticlate Patient Counseling
See Literature
Acticlate Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 75mg, 150mg+; tabs; +scored; contains sodium.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs—60
Manufacturer
Acticlate Indications
Indications
Short term prophylaxis of malaria due to P. falciparum in areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains.
Acticlate Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. ≥8yrs (<45kg): 2mg/kg once daily; (≥45kg): use Adults dose; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.
Acticlate Contraindications
Not Applicable
Acticlate Boxed Warnings
Not Applicable
Acticlate Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy. Nursing mothers: not recommended (during and for 5 days after the last dose).
Acticlate Pharmacokinetics
See Literature
Acticlate Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Acticlate Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, inhibition of bone growth, intracranial hypertension, C.difficile-associated diarrhea, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Acticlate Clinical Trials
See Literature
Acticlate Note
Not Applicable
Acticlate Patient Counseling
See Literature
Acticlate Generic Name & Formulations
Legal Class
Rx
General Description
Doxycycline (as hyclate) 75mg, 150mg+; tabs; +scored; contains sodium.
Pharmacological Class
Tetracycline antibiotic.
How Supplied
Tabs—60
Manufacturer
Acticlate Indications
Indications
Adjunct in acute intestinal amebiasis.
Acticlate Dosage and Administration
Adult
Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours); if severe infections: 100mg every 12 hours.
Children
≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose.
Acticlate Contraindications
Not Applicable
Acticlate Boxed Warnings
Not Applicable
Acticlate Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy. Nursing mothers: not recommended (during and for 5 days after the last dose).
Acticlate Pharmacokinetics
See Literature
Acticlate Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.
Acticlate Adverse Reactions
Adverse Reactions
Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, inhibition of bone growth, intracranial hypertension, C.difficile-associated diarrhea, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Acticlate Clinical Trials
See Literature
Acticlate Note
Not Applicable
Acticlate Patient Counseling
See Literature
