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Acthrel Generic Name & Formulations
Legal Class
Rx
General Description
Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.
Pharmacological Class
Corticotropin-releasing hormone (CRH) analogue.
How Supplied
Single-dose vial—1
Manufacturer
Acthrel Indications
Indications
For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.
Acthrel Dosage and Administration
Adults and Children
Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.
Acthrel Contraindications
Not Applicable
Acthrel Boxed Warnings
Not Applicable
Acthrel Warnings/Precautions
Warnings/Precautions
Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.
Acthrel Pharmacokinetics
See Literature
Acthrel Interactions
Interactions
Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.
Acthrel Adverse Reactions
Adverse Reactions
Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.
Acthrel Clinical Trials
See Literature
Acthrel Note
Not Applicable
Acthrel Patient Counseling
See Literature
