Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Acetadote Generic Name & Formulations
Legal Class
Rx
General Description
Acetylcysteine 200mg/mL; soln for IV infusion after dilution; preservative-free.
How Supplied
Single-use vial (30mL)—4
Manufacturer
Generic Availability
YES
Acetadote Indications
Indications
To minimize hepatic injury after acetaminophen overdose.
Acetadote Dosage and Administration
Adults and Children
Administer within 8 hours for maximal protection against hepatic injury. Estimate time of acetaminophen ingestion. If <24 hours since overdose, obtain serum acetaminophen level 4 hours post-ingestion or as soon as possible thereafter and plot level on nomogram, draw second level 4–6 hours after first; if either falls above toxicity line, initiate therapy. If >8 hours post-ingestion, start treatment immediately. If time of ingestion unknown: consider empiric initiation of treatment. 300mg/kg given as 3 separate doses and administered over a total of 21 hours. See full labeling for preparation based on patient weight. >100kg: loading dose: 15,000mg over 1 hour; first maintenance dose: 5,000mg over 4 hours; second maintenance dose: 10,000mg over 16 hours.
Acetadote Contraindications
Not Applicable
Acetadote Boxed Warnings
Not Applicable
Acetadote Warnings/Precautions
Warnings/Precautions
Asthma. History of bronchospasm. Monitor for severe hypersensitivity reactions; may treat with antihistamines and epinephrine; interrupt or discontinue treatment if persistent. Avoid fluid overload esp. in patients <40kg or those requiring fluid restriction; reduce volume of diluent as needed (see full labeling). Monitor liver enzymes, INR, creatinine, BUN, blood glucose, electrolytes. Hepatic or renal impairment: see full labeling. Pregnancy. Nursing mothers (pump and discard milk for 30hrs after therapy).
Acetadote Pharmacokinetics
See Literature
Acetadote Interactions
Not Applicable
Acetadote Adverse Reactions
Adverse Reactions
Hypersensitivity reactions (eg, rash, urticaria/facial flushing, pruritus, edema, hypotension, cough, wheezing, SOB, bronchospasm), GI upset, tachycardia.
Acetadote Clinical Trials
See Literature
Acetadote Note
Not Applicable
Acetadote Patient Counseling
See Literature
