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Abelcet Generic Name & Formulations
Legal Class
Rx
General Description
Amphotericin B lipid complex 5mg/mL; susp for IV infusion after dilution; preservative-free.
Pharmacological Class
Polyene antifungal.
How Supplied
Single-use vials (50mg, 100mg)—1 (w. filter needle)
Manufacturer
Abelcet Indications
Indications
Invasive fungal infections in patients who are refractory to, or intolerant of, conventional amphotericin B therapy.
Abelcet Dosage and Administration
Adults and Children
5mg/kg daily as a single IV infusion, at a rate of 2.5mg/kg per hour. Renal impairment: reduce dose.
Abelcet Contraindications
Not Applicable
Abelcet Boxed Warnings
Not Applicable
Abelcet Warnings/Precautions
Warnings/Precautions
Be fully familiar with the use of this product. Administer under close supervision; cardiopulmonary resuscitation facilities should be available. Monitor CBC, serum creatinine, liver function, serum electrolytes (esp. magnesium and potassium). Pregnancy (Cat.B). Nursing mothers: not recommended.
Abelcet Pharmacokinetics
See Literature
Abelcet Interactions
Interactions
Monitor other drugs; see full labeling. Caution with antineoplastics, corticosteroids, ACTH, cyclosporine, digitalis glycosides, flucytosine, imidazoles, nephrotoxic drugs, skeletal muscle relaxants, zidovudine. Concurrent leukocyte transfusion: not recommended.
Abelcet Adverse Reactions
Adverse Reactions
Infusion reactions (1–2 hrs post-infusion, eg, transient chills/fever, rarely: bronchospasm, hypotension, arrhythmias, shock), nephrotoxicity, hepatotoxicity, anaphylaxis, respiratory/cardiac/neurological disorders, malaise, tinnitus, visual impairment, hearing loss, diarrhea; others: see literature.
Abelcet Clinical Trials
See Literature
Abelcet Note
Not Applicable
Abelcet Patient Counseling
See Literature
