Seizure disorders Archives - MPR

ACTHAR GEL

Haymarket Media — Mon, 06 Feb 2023 21:00:52 +0000

Repository corticotrophin 80 Units/mL; gel for IM or SC Inj.

Additional Administration Options Approved for Seizure Medication Xcopri

Steve Duffy — Thu, 11 Apr 2024 17:15:00 +0000

The Food and Drug Administration (FDA) has approved 2 new administration options for Xcopri^® (cenobamate tablets) for the treatment of adults with partial-onset seizures.

Xcopri tablets can now either be swallowed whole or be crushed. The crushed tablet can be mixed with water and either administered by mouth as an oral suspension or administered via a nasogastric tube.

The labeling update is supported by data from an open-label, randomized, single-center, 3-period, 6-sequence, balanced crossover study. Findings showed the plasma Cmax and AUC for Xcopri crushed tablets mixed in water, administered either orally or through a nasogastric tube, were similar to whole tablets.

“The approval addresses the needs of patients living with epilepsy who are currently taking, or who may benefit from starting Xcopri, but are unable to swallow the tablets whole,” said Louis Ferrari, BS, RPh, MBA, vice president, Medical Affairs at SK Life Science. “In some patients, crushing tablets offers an additional option for dosing and administration by nasogastric tube. This label update addresses an unmet need for this patient population and offers administration alternatives to the health care providers managing their care.”

Xcopri is available as 12.5mg-, 25mg-, 50mg-, 100mg-, 150mg-, and 200mg-strength tablets.

Antiepileptic Drug Indications

Haymarket Media — Sat, 15 Sep 2018 18:39:42 +0000

Antiepileptic Drug Indications

ANTIEPILEPTIC DRUG INDICATIONS
				Partial		Generalized
Generic	Brand		Form	Simple	Complex	Absence	Myoclonic	Tonic-clonic	Atonic	Mixed	Status Epilepticus	Lennox-Gastaut	Others⁷
Adrenocorticotropic Hormone (Acth) Analogue
corticotrophin	H.P. Acthar Gel	℞	gel for IM, SC inj										√
Alpha-2 Delta Ligand
pregabalin	Lyrica	CV	caps, oral susp	√¹	√¹
AMPA GLUTAMATE RECEPTOR ANTAGONIST
perampanel	Fycompa	CIII	tabs, oral susp	√	√			√¹
ANTIEPILEPTICS
brivaracetam	Briviact	CV	tabs, oral soln, IV inj	√	√
cenobamate	Xcopri	CV	tabs	√	√
divalproex sodium	Depakote	℞	del-rel tabs		√	√							√¹
	Depakote ER	℞	ext-rel tabs		√	√							√¹
	Depakote Sprinkle	℞	del-rel coated particles in caps		√	√							√¹
gabapentin	Neurontin	℞	caps, tabs, oral soln	√¹	√¹
levetiracetam	Keppra	℞	tabs, oral soln, IV inj	√	√		√¹	√¹
	Keppra XR	℞	ext-rel tabs	√	√
	Spritam	℞	tabs for oral susp	√	√		√¹	√¹
rufinamide	Banzel	℞	tabs, oral susp									√¹
stiripentol	Diacomit	℞	caps, oral susp										√
valproate sodium	—	℞	IV inj		√²	√²							√^1,2
valproic acid	—	℞	caps, syrup		√	√							√¹
vigabatrin	Sabril	℞	tabs, pwd for oral soln		√^1,3								√
BARBITURATE
phenobarbital	Sezaby	CIV	IV inj										√
primidone	Mysoline	℞	tabs	√	√			√
BENZODIAZEPINE
clobazam	Onfi	CIV	tabs, oral soln									√¹
clobazam	Sympazan	CIV	oral films									√¹
clonazepam	—	CIV	ODT			√³	√		√			√
clonazepam	Klonopin	CIV	tabs			√³	√		√			√
diazepam	—	CIV	IM, IV inj								√¹		√¹
	—	CIV	oral soln	√¹	√¹	√¹	√¹	√^1,5	√¹	√¹		√¹
	Diastat	CIV	rectal gel										√
	Diazepam Intensol	CIV	oral soln	√¹	√¹	√¹	√¹	√^1,5	√¹	√¹		√¹
	Valium	CIV	tabs	√¹	√¹	√¹	√¹	√^1,5	√¹	√¹		√¹
	Valtoco	CIV	nasal spray										√
lorazepam	Ativan	CIV	IM, IV inj								√
midazolam	Nayzilam	CIV	nasal spray										√
midazolam	Seizalam	CIV	IM inj								√
CANNABINOID
cannabidiol	Epidiolex	CV	oral soln									√	√
DIBENZAZEPINE
carbamazepine	Carbatrol	℞	ext-rel caps	√	√			√		√
	Equetro	℞	ext-rel caps		√			√		√
	Tegretol	℞	tabs, oral susp	√	√			√		√
	Tegretol XR	℞	ext-rel tabs	√	√			√		√
eslicarbazepine	Aptiom	℞	tabs	√	√
oxcarbazepine	Oxtellar XR	℞	ext-rel tabs	√	√
oxcarbazepine	Trileptal	℞	tabs, oral susp	√	√
GABA_A RECEPTOR MODULATOR
ganaxolone	Ztalmy	CV	oral susp										√
HYDANTOIN
fosphenytoin	Cerebyx	℞	IV, IM inj		√²			√²			√⁶		√
phenytoin	—	℞	IV inj								√⁶		√
	Dilantin	℞	ext-rel caps, oral susp		√			√					√
	Dilantin Infatabs	℞	chew tabs		√			√					√
	Phenytek	℞	ext-rel caps		√			√					√
PHENYLTRIAZINE
lamotrigine	Lamictal	℞	tabs, chew tabs, ODT	√^1,4	√^1,4			√¹				√¹
lamotrigine	Lamictal XR	℞	ext-rel tabs	√^1,4	√^1,4			√¹
SODIUM CHANNEL INACTIVATOR
lacosamide	Vimpat	CV	tabs, oral soln, IV inj	√	√			√¹
SUCCINIMIDE
ethosuximide	Zarontin	℞	caps, syrup			√
methsuximide	Celontin	℞	caps			√³
SULFAMATE
topiramate	—	℞	coated beads in caps	√	√			√				√¹
	Eprontia	℞	oral soln	√	√			√				√¹
	Qudexy XR	℞	ext-rel caps	√	√			√				√¹
	Topamax	℞	caps, tabs	√	√			√				√¹
	Trokendi XR	℞	ext-rel caps	√	√			√				√¹
SULFONAMIDE
zonisamide	Zonegran	℞	caps	√¹	√¹
SYMPATHOMIMETIC
fenfluramine	Fintepla	CIV	oral soln									√	√
NOTES
Key: AED = antiepileptic drug; del-rel = delayed-release; ext-rel = extended-release; ODT = orally-disintegrating tablets ¹ Adjunct therapy only. ² Temporary alternative to oral therapy. ³ Only if refractory to other therapy. ⁴ Conversion to monotherapy in adults with partial seizures who are on a single AED (see full labeling). ⁵ Also indicated for tonic seizure. ⁶ For generalized tonic-clonic status epilepticus. ⁷ Other indications include infantile spasms, neonatal seizures, Dravet syndrome, recurrent seizures, multiple seizure types, cluster seizures (episodes of increased seizure activity), neurosurgically-induced seizures, seizures due to cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder; see full labeling. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 6/2023)

APTIOM

Haymarket Media — Thu, 22 Jul 2021 11:32:33 +0000

Eslicarbazepine acetate 200mg+, 400mg, 600mg+, 800mg+; (+) scored tabs.

ATIVAN INJECTION

Haymarket Media — Fri, 17 Feb 2023 16:02:30 +0000

Lorazepam 2mg/mL, 4mg/mL; soln for IV inj after dilution or IM inj; contains polyethylene glycol 400 in propylene glycol, benzyl alcohol.

BANZEL

Haymarket Media — Thu, 22 Jul 2021 11:06:40 +0000

Rufinamide 200mg, 400mg; scored tabs.

BANZEL ORAL SUSPENSION

Haymarket Media — Thu, 22 Jul 2021 11:17:24 +0000

Rufinamide 40mg/mL; orange-flavor; lactose-, gluten-, and dye-free.

BRIVIACT

Haymarket Media — Thu, 01 Jun 2023 18:31:31 +0000

Brivaracetam 10mg, 25mg, 50mg, 75mg, 100mg; tabs.

BRIVIACT INJECTION

Haymarket Media — Wed, 01 Sep 2021 18:50:21 +0000

Brivaracetam 50mg/5mL; soln for IV inj; preservative-free.

BRIVIACT ORAL SOLUTION

Haymarket Media — Wed, 01 Sep 2021 18:50:45 +0000

Brivaracetam 10mg/mL; raspberry flavored.

Carbamazepine Dosing

Haymarket Media — Thu, 04 Feb 2016 02:25:05 +0000

Start Over

Start Over

CARBATROL

Haymarket Media — Mon, 01 May 2023 19:51:38 +0000

Carbamazepine 100mg, 200mg, 300mg; ext-rel caps.

CELONTIN

Haymarket Media — Thu, 22 Jul 2021 11:30:04 +0000

Methsuximide 300mg; caps.

CEREBYX

Haymarket Media — Thu, 22 Jul 2021 11:15:02 +0000

Fosphenytoin sodium (prodrug of phenytoin) 75mg/mL (equivalent to 50mg/mL phenytoin sodium); soln for IV or IM inj.

Clonazepam Orally-Disintegrating Tabs

Haymarket Media — Fri, 17 Feb 2023 17:37:25 +0000

Clonazepam 0.125mg, 0.25mg, 0.5mg, 1mg, 2mg; orally-disintegrating tabs.

Corrected Phenytoin (Albumin)

Haymarket Media — Wed, 03 Feb 2016 20:42:27 +0000

Start Over

Start Over

DEPAKOTE

Haymarket Media — Mon, 13 Mar 2023 18:33:43 +0000

Divalproex sodium 125mg, 250mg, 500mg; del-rel tabs.

DEPAKOTE ER

Haymarket Media — Mon, 13 Mar 2023 18:34:50 +0000

Divalproex sodium 250mg, 500mg; ext-rel tabs.

DEPAKOTE SPRINKLE

Haymarket Media — Mon, 13 Mar 2023 18:34:25 +0000

Divalproex sodium 125mg; coated particles in caps.

DIACOMIT

Haymarket Media — Tue, 16 Aug 2022 13:21:53 +0000

Stiripentol 250mg, 500mg; caps.

DIACOMIT ORAL SUSP

Haymarket Media — Tue, 16 Aug 2022 13:22:35 +0000

Stiripentol 250mg, 500mg; per packet; pwd for oral susp; fruit flavor; contains phenylalanine.

DIASTAT

Haymarket Media — Thu, 23 Feb 2023 20:33:42 +0000

Diazepam 2.5mg, 10mg, 20mg; per applicator; rectal gel.

Diazepam Injection

Haymarket Media — Fri, 17 Feb 2023 19:51:34 +0000

Diazepam 5mg/mL; soln for IM or IV use; contains propylene glycol 40%, ethyl and benzyl alcohol.

Diazepam Intensol

Haymarket Media — Thu, 23 Feb 2023 20:18:23 +0000

Diazepam 5mg; per 1mL; concentrated soln; contains alcohol 19%.

Diazepam Oral Solution

Haymarket Media — Thu, 23 Feb 2023 20:18:06 +0000

Diazepam 5mg; per 5mL; wintergreen-spice flavor.