Hormone Replacement Therapies

HORMONE REPLACEMENT THERAPIES
Generic	Brand	Strength	Form	Dosing Frequency
ORAL ESTROGEN
conjugated estrogens	Premarin	0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg	tabs	Once daily
esterified estrogens	Menest	0.3mg, 0.625mg, 1.25mg, 2.5mg	tabs
estradiol (micronized)	Estrace	0.5mg, 1mg, 2mg	tabs
TRANSDERMAL ESTROGEN
estradiol	Climara	0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day	transdermal system	Once weekly
	Divigel	0.25mg/pkt, 0.5mg/pkt, 0.75mg/pkt, 1mg/pkt, 1.25mg/pkt	topical gel	Once daily
	Elestrin	0.87g/pump	topical gel	Once daily
	Estrogel	1.25g/pump	topical gel	1 pump once daily
	Evamist	1.53mg/spray	transdermal spray	Initially 1 spray daily; may increase to 2−3 sprays if needed
	Menostar	14mcg/day	transdermal system	Once weekly
	Minivelle	0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day	trans– dermal system	Twice weekly
	Vivelle-Dot	0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day	transdermal system	Twice weekly
VAGINAL ESTROGEN
conjugated estrogens	Premarin	0.625mg/g	cream	Once daily or twice weekly, cyclically*
estradiol	Estring	7.5mcg/24hrs	ring	Once every 90 days
	Femring	0.05mg/day, 0.1mg/day	ring	Once every 3mos
	Imvexxy	4mcg, 10mcg	vaginal inserts	Initially 4mcg once daily for 2wks, then twice weekly every 3–4 days
	Vagifem	10mcg	vaginal inserts	Once daily for 2wks, then twice weekly
ORAL ESTROGEN + ESTROGEN AGONIST/ANTAGONIST
conjugated estrogens/ bazedoxifene	Duavee	0.45mg/20mg	tabs	Once daily
ORAL PROGESTOGEN
medroxyprogesterone acetate	Provera	2.5mg, 5mg, 10mg	tabs	Once daily
norethindrone acetate	—	5mg	tabs
progesterone (micronized)	Prometrium	100mg, 200mg	caps
ORAL ESTROGEN + PROGESTOGEN
conjugated estrogens (14 tabs); then conjugated estrogens/ MPA (14 tabs)	Premphase	0.625mg; then 0.625mg/5mg	tabs	Once daily, sequentially
conjugated estrogens/ MPA (28 tabs)	Prempro	0.3mg/1.5mg, 0.45mg/1.5mg, 0.625mg/ 2.5mg, 0.625mg/5mg	tabs	Once daily
estradiol/ drospirenone	Angeliq	0.5mg/0.25mg, 1mg/0.5mg	tabs	Once daily
estradiol/ norethindrone acetate	Activella	0.5mg/0.1mg, 1mg/0.5mg	tabs	Once daily
estradiol/ progesterone	Bijuva	0.5mg/100mg, 1mg/100mg	caps	Initially 0.5mg/100mg once daily in PM; adjust based on response
norethindrone acetate/ ethinyl estradiol	—	0.5mg/2.5mcg, 1mg/5mcg	tabs	Once daily Note: Progestin listed first
TRANSDERMAL ESTROGEN + PROGESTOGEN
estradiol/ levonorgestrel	Climara Pro	0.045mg/ 0.015mg per day	transdermal system	Once weekly
estradiol/ norethindrone acetate	Combipatch	0.05mg/ 0.14mg per day, 0.05mg/ 0.25mg per day	transdermal system	Twice weekly
NOTES
*Once daily for atrophic vaginitis or kraurosis vulvae. Twice weekly for dyspareunia. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Estrogen component is listed first for combination products. Listed strengths are not necessarily the same as the dosage. Listed dosing frequency is for use in HRT; may be other frequencies for other uses. Some products are given cyclically. (Rev. 4/2024)

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