Antiepileptic Drug Indications

Antiepileptic Drug Indications

ANTIEPILEPTIC DRUG INDICATIONS
Partial Generalized
Generic Brand Form Simple Complex Absence Myoclonic Tonic-clonic Atonic Mixed Status Epilepticus Lennox-Gastaut Others7
Adrenocorticotropic Hormone (Acth) Analogue
corticotrophin H.P. Acthar Gel ℞ gel for IM, SC inj √
Alpha-2 Delta Ligand
pregabalin Lyrica CV caps, oral susp √1 √1
AMPA GLUTAMATE RECEPTOR ANTAGONIST
perampanel Fycompa CIII tabs, oral susp √ √ √1
ANTIEPILEPTICS
brivaracetam Briviact CV tabs, oral soln, IV inj √ √
cenobamate Xcopri CV tabs √ √
divalproex sodium Depakote ℞ del-rel tabs √ √ √1
Depakote ER ℞ ext-rel tabs √ √ √1
Depakote Sprinkle ℞ del-rel coated particles in caps √ √ √1
gabapentin Neurontin ℞ caps, tabs, oral soln √1 √1
levetiracetam Keppra ℞ tabs, oral soln, IV inj √ √ √1 √1
Keppra XR ℞ ext-rel tabs √ √
Spritam ℞ tabs for oral susp √ √ √1 √1
rufinamide Banzel ℞ tabs, oral susp √1
stiripentol Diacomit ℞ caps, oral susp √
valproate sodium — ℞ IV inj √2 √2 √1,2
valproic acid — ℞ caps, syrup √ √ √1
vigabatrin Sabril ℞ tabs, pwd for oral soln √1,3 √
BARBITURATE
phenobarbital Sezaby CIV IV inj √
primidone Mysoline ℞ tabs √ √ √
BENZODIAZEPINE
clobazam Onfi CIV tabs, oral soln √1
Sympazan CIV oral films √1
clonazepam — CIV ODT √3 √ √ √
Klonopin CIV tabs √3 √ √ √
diazepam — CIV IM, IV inj √1 √1
oral soln √1 √1 √1 √1 √1,5 √1 √1 √1
Diastat CIV rectal gel √
Diazepam Intensol CIV oral soln √1 √1 √1 √1 √1,5 √1 √1 √1
Valium CIV tabs √1 √1 √1 √1 √1,5 √1 √1 √1
Valtoco CIV nasal spray √
lorazepam Ativan CIV IM, IV inj √
midazolam Nayzilam CIV nasal spray √
Seizalam CIV IM inj √
CANNABINOID
cannabidiol Epidiolex CV oral soln √ √
DIBENZAZEPINE
carbamazepine Carbatrol ℞ ext-rel caps √ √ √ √
Equetro ℞ ext-rel caps √ √ √
Tegretol ℞ tabs, oral susp √ √ √ √
Tegretol XR ℞ ext-rel tabs √ √ √ √
eslicarbazepine Aptiom ℞ tabs √ √
oxcarbazepine Oxtellar XR ℞ ext-rel tabs √ √
Trileptal ℞ tabs, oral susp √ √
GABAA RECEPTOR MODULATOR
ganaxolone Ztalmy CV oral susp √
HYDANTOIN
fosphenytoin Cerebyx ℞ IV, IM inj √2 √2 √6 √
phenytoin — ℞ IV inj √6 √
Dilantin ℞ ext-rel caps, oral susp √ √ √
Dilantin Infatabs ℞ chew tabs √ √ √
Phenytek ℞ ext-rel caps √ √ √
PHENYLTRIAZINE
lamotrigine Lamictal ℞ tabs, chew tabs, ODT √1,4 √1,4 √1 √1
Lamictal XR  ℞ ext-rel tabs √1,4 √1,4 √1
SODIUM CHANNEL INACTIVATOR
lacosamide Vimpat CV tabs, oral soln, IV inj √ √ √1
SUCCINIMIDE
ethosuximide Zarontin ℞ caps, syrup √
methsuximide Celontin ℞ caps √3
SULFAMATE
topiramate — ℞ coated beads in caps √ √ √ √1
Eprontia ℞ oral soln √ √ √ √1
Qudexy XR ℞ ext-rel caps √ √ √ √1
Topamax ℞ caps, tabs √ √ √ √1
Trokendi XR ℞ ext-rel caps √ √ √ √1
SULFONAMIDE
zonisamide Zonegran ℞ caps √1 √1
SYMPATHOMIMETIC
fenfluramine Fintepla CIV oral soln √ √
NOTES

Key: AED = antiepileptic drug; del-rel = delayed-release; ext-rel = extended-release; ODT = orally-disintegrating tablets

1 Adjunct therapy only.

2 Temporary alternative to oral therapy.

3 Only if refractory to other therapy.

4 Conversion to monotherapy in adults with partial seizures who are on a single AED (see full labeling).

5 Also indicated for tonic seizure.

6 For generalized tonic-clonic status epilepticus.

7 Other indications include infantile spasms, neonatal seizures, Dravet syndrome, recurrent seizures, multiple seizure types, cluster seizures (episodes of increased seizure activity), neurosurgically-induced seizures, seizures due to cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder; see full labeling.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 6/2023)

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