Androgens- MPR

Androgens

ANDROGENS
Generic	Brand	Strength	Dose
Capsules
methyl– testosterone	—	10mg	Adults and Children: Usually 10−50mg daily. Delayed puberty: use low dose and limit duration to 4−6mos.
testosterone undecanoate	Jatenzo	158mg, 198mg, 237mg	≥18yrs: Initially 237mg twice daily (AM + PM) with food; max 396mg twice daily. <18yrs: Not established.
	Kyzatrex	100mg, 150mg, 200mg	≥18yrs: 200mg twice daily (AM + PM); max 400mg twice daily. <18yrs: Not established.
	Tlando	112.5mg	≥18yrs: 225mg (2 caps) twice daily (AM + PM). <18yrs: Not established.
INTRAMUSCULAR INJECTION
testosterone cypionate	Depo-Testos– terone	100mg/mL, 200mg/mL	Adults: Give by deep IM inj into gluteal muscle once every 2−4wks. 50−400mg; max 400mg/month. Children: <12yrs: Not established.
testosterone enanthate	—	200mg/mL	Adults: Give by deep IM inj into gluteal muscle once every 2−4wks. Male hypogonadism: 50−400mg. Delayed puberty: 50–200mg for 4–6mos. Max 400mg/month. Children: See full labeling.
testosterone undecanoate	Aveed	250mg/mL	≥18yrs: Give by deep IM inj into gluteal muscle. 3mL (750mg) once at initiation, followed by 3mL (750mg) at 4wks, then 3mL (750mg) every 10wks thereafter. <18yrs: Not established.
NASAL GEL
testosterone	Natesto	5.5mg/ 0.122g per pump actuation	≥18yrs: Administer intranasally once in the morning, afternoon, and evening (6−8hrs apart) at same time each day. 11mg (1 pump per nostril) three times daily (total dose: 33mg daily); check serum testosterone levels periodically as soon as one month after initiation. <18yrs: Not established.
SUBCUTANEOUS INJECTION
testosterone enanthate	Xyosted	50mg/0.5mL, 75mg/0.5mL, 100mg/0.5mL	≥18yrs: Give by SC inj into abdomen. Male hypogonadism: 75mg once weekly. Decrease by 25mg if total testosterone trough level ≥650ng/dL; or, increase by 25mg if <350ng/dL. <18yrs: Not established.
Tablets
methyl– testosterone	—	10mg	Adults and Children: Usually 10−50mg daily. Delayed puberty: use low dose and limit duration to 4−6mos
TRANSDERMAL GEL
testosterone	testosterone 1%*	25mg/2.5g, 50mg/5g pkt	≥18yrs: Apply to clean, intact, dry skin of the shoulders, upper arms, and/or abdomen; do not apply to genitals, chest, axillae, knees, or back. 5g (50mg of testosterone) once daily in AM; check serum testosterone level at intervals until normal range; may increase to 7.5g/day (75mg of testosterone), then to 10g/day (100mg of testosterone) if needed. <18yrs: Not established.
	Androgel 1.62%*	20.25mg/ 1.25g per pump actuation	≥18yrs: Apply to clean, intact, dry skin of the shoulders and upper arms; do not apply to abdomen, genitals, chest, axillae, or knees. 2.5g (40.5mg of testosterone [2 pump actuations]) once daily in AM. May adjust dose between min of 20.25mg (1 pump actuation) and a max of 81mg (4 pump actuations) based on the pre‑dose morning serum testosterone concentration at approx. 14 days and 28 days after starting treatment or following dose adjustment. <18yrs: Not established.
	Fortesta*	10mg/0.5g per pump actuation	≥18yrs: Apply to clean, dry, intact skin on front and inner thighs only. Initially 40mg (4 pump actuations) once daily in the AM. Adjust based on serum testosterone levels (see full labeling); min: 10mg/day, max: 70mg/day. <18yrs: Not established.
	Testim*	50mg/5g per tube	≥18yrs: Apply to clean, dry intact skin of the shoulders and/or upper arms; do not apply to genitals or abdomen. Initially 50mg (1 tube) once daily; check morning, pre-dose serum testosterone levels approx. 14 days after initiation. May increase to 100mg (2 tubes) once daily based on serum testosterone concentration; max 100mg once daily. <18yrs: Not recommended.
	Vogelxo*	50mg/5g per tube or pkt	≥18yrs: Apply to clean, dry intact skin of the shoulders and/or upper arms at the same time each day; do not apply to the genitals or abdomen. Initially 50mg (1 tube or pkt, or 4 pump actuations) once daily; check morning, pre‑dose serum testosterone levels approx. 14 days after initiation. May increase to 100mg (2 tubes or pkts, or 8 pump actuations) once daily based on serum testosterone concentration; max 100mg once daily. <18yrs: Not established.
	Vogelxo*	12.5mg/ 1.25g per pump actuation
NOTES
Prior to the above treatments, confirm diagnosis by ensuring serum testosterone is below normal range as measured in the AM on at least 2 separate days. Monitor serum testosterone levels periodically during therapy. *Wash hands after application. Do not wash site for at least 2hrs after application. Allow gel or solution to dry before covering with clothing. Advise patients to strictly adhere to recommended instructions. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 1/2024)

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