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Hypertension Treatments: Diuretics
| HYPERTENSION TREATMENTS: DIURETICS | ||||
|---|---|---|---|---|
| Generic | Brand | Strength | Form | Usual Dose |
| LOOP DIURETICS | ||||
| furosemide | — | 10mg/ mL, 40mg/ 5mL |
oral soln | Adults: Initially 40mg twice daily. Adding to other antihypertensives: Initially reduce other agent’s dose by 50%. Children: Not recommended. |
| 20mg, 40mg+, 80mg+ | tabs | |||
| Lasix | 20mg, 40mg+, 80mg+ | tabs | ||
| torsemide | — | 5mg, 10mg, 20mg, 100mg | scored tabs | Adults: Initially 5mg once daily; may increase to 10mg daily after 4–6wks. Children: Not established. |
| POTASSIUM SPARING DIURETICS | ||||
| amiloride | — | 5mg | tabs | Adults: Administer with kaliuretic and food. Initially 5mg/day; 5−10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring. Children: Not established. |
| eplerenone | Inspra | 25mg, 50mg | tabs | Adults: Initially 50mg once daily; may increase after 4wks to max 50mg twice daily. Concomitant moderate CYP3A inhibitors (eg, erythromycin, verapamil, saquinavir, fluconazole): initially 25mg once daily; max 25mg twice daily. Children: Not established. |
| spirono– lactone |
Aldactone | 25mg, 50mg+, 100mg+ | tabs | Adults: Initially 25−100mg/day in single or divided doses. Titrate at 2‑wk intervals. Children: Not established. |
| Carospir | 25mg/5mL | oral susp | Adults: Initially 20–75mg (4–15mL) daily in single or divided doses. Titrate at 2-wk intervals. If dose >100mg required, use another formulation. Children: Not established. |
|
| POTASSIUM SPARING + THIAZIDE DIURETICS | ||||
| amiloride/ hydrochloro– thiazide |
— | 5mg/ 50mg |
scored tabs | Adults: Initially 1 tab daily with food. May increase to 2 tabs daily in single or divided doses. Children: Not established. |
| spirono– lactone/ hydrochloro– thiazide |
Aldactazide | 25mg/ 25mg, 50mg/ 50mg+ |
tabs | Adults: Usual maintenance: 50−100mg each of spironolactone and HCTZ daily in single or divided doses. Children: Not established. |
| triamterene/ hydrochloro– thiazide |
— | 37.5mg/ 25mg |
caps | Adults: 1−2 caps once daily. Children: Not established. |
| Maxzide-25mg | 37.5mg/ 25mg |
scored tabs | Adults: 1−2 tabs once daily. Children: Not established. |
|
| Maxzide | 75mg/ 50mg |
scored tabs | Adults: 1 tab daily. Children: Not established. |
|
| THIAZIDE-LIKE DIURETICS | ||||
| chlortha– lidone |
— | 25mg, 50mg+ | tabs | Adults: Initially 25mg once daily; may increase to 50mg once daily if needed. If inadequate, increase to 100mg once daily or add second agent. Maintenance: doses may be lower than initial doses; individualize. Children: Not established. |
| hydrochloro– thiazide |
— | 12.5mg, 25mg+, 50mg+ | tabs | Adults: Initially 25mg once daily; usual max 50mg/day in 1–2 divided doses. Children:<6mos: up to 3mg/kg/day in 2 divided doses. ≥6mos: 1–2mg/kg/day in 1–2 divided doses. Max (<2yrs): 37.5mg/day; (2–12yrs): 100mg/day. |
| Microzide | 12.5mg | caps | Adults: 12.5mg once daily; usual max 50mg/day. Children: Not established. |
|
| indapamide | — | 1.25mg, 2.5mg | tabs | Adults: Initially 1.25mg once daily in the AM. May adjust at 4‑wk intervals to 2.5mg then 5mg once daily. Children: Not established. |
| metolazone | — | 2.5mg, 5mg, 10mg | tabs | Adults: 2.5−5mg once daily. Children: Not established. |
| NOTES | ||||
|
Key: + = scored tablets Not an inclusive list of medications. Please see drug monographs at www.eMPR.com and/or contact company for full drug labeling. (Rev. 9/2023) |
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