Dyslipidemia Drug Indications- MPR

Dyslipidemia Drug Indications

DYSLIPIDEMIA DRUG INDICATIONS
Generic	Brand	Form	Indications
Generic	Brand	Form	Slow coronary athero- sclerosis	Lower total-C	Lower LDL-C	Increase HDL-C	Lower apo B	Lower TG	Sitosterol/ campe- sterol	Reduce risk of CVD⁴
ADENOSINE TRIPHOSPHATE-CITRATE LYASE (ACL) INHIBITOR + CHOLESTEROL ABSORPTION INHIBITOR
bempedoic acid + ezetimibe	Nexlizet	tabs		✓	✓		✓
ANGIOPOIETIN-LIKE 3 (ANGPTL3) INHIBITOR
evinacumab-dgnb	Evkeeza	IV inj		✓	✓		✓	✓
BILE ACID SEQUESTRANTS
cholestyr– amine resin	—	pwd		✓						✓
colesevelam	Welchol	tabs, oral susp			✓
colestipol	Colestid	tabs, granules		✓	✓
CHOLESTEROL ABSORPTION INHIBITOR
ezetimibe	Zetia	tabs		✓	✓		✓		✓²
FIBRATES
fenofibrate	Antara	caps		✓	✓	✓	✓	✓
	Fenoglide	tabs		✓	✓	✓	✓	✓
	Lipofen	caps		✓	✓	✓	✓	✓
	Tricor	tabs		✓	✓	✓	✓	✓
	Triglide	tabs		✓	✓	✓	✓	✓
fenofibric acid	Trilipix	del-rel caps		✓	✓	✓	✓	✓
LIPID-REGULATING AGENT
gemfibrozil	Lopid	scored tabs	✓¹					✓		✓
icosapent ethyl	Vascepa	caps						✓		✓
omega-3-acid ethyl esters	Lovaza	caps						✓
MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITOR
lomitapide mesylate	Juxtapid	caps		✓	✓³		✓
NICOTINIC ACID DERIVATIVES
niacin	—	ext-rel tabs	✓	✓	✓	✓	✓	✓		✓
PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) INHIBITOR
alirocumab	Praluent	SC inj		✓	✓		✓			✓
evolocumab	Repatha	SC inj		✓	✓		✓			✓
evolocumab	Repatha Pushtronex	SC inj		✓	✓		✓			✓
SMALL INTERFERING RNA (siRNA)
inclisiran	Leqvio	SC inj		✓	✓		✓
STATINS (HMG-CoA REDUCTASE INHIBITORS)
atorvastatin	Atorvaliq	oral susp		✓	✓	✓	✓	✓		✓
atorvastatin	Lipitor	tabs		✓	✓	✓	✓	✓		✓
fluvastatin	—	caps	✓	✓	✓	✓	✓	✓		✓
fluvastatin	Lescol XL	ext-rel tabs	✓	✓	✓	✓	✓	✓		✓
lovastatin	—	tabs	✓	✓	✓	✓	✓			✓
lovastatin	Altoprev	ext-rel tabs	✓	✓	✓	✓	✓	✓		✓
pitavastatin	Livalo	tabs		✓	✓	✓	✓	✓
pitavastatin	Zypitamag	tabs		✓	✓	✓	✓	✓
pravastatin	—	tabs	✓	✓	✓	✓	✓	✓		✓
rosuvastatin	Crestor	tabs	✓	✓	✓³	✓	✓	✓		✓
rosuvastatin	Ezallor Sprinkle	caps		✓	✓	✓	✓	✓
simvastatin	Zocor	tabs		✓	✓	✓	✓	✓		✓
STATIN + CALCIUM CHANNEL BLOCKER
atorvastatin + amlodipine	Caduet	tabs		✓	✓	✓	✓	✓		✓
STATIN + CHOLESTEROL ABSORPTION INHIBITOR
simvastatin + ezetimibe	Vytorin	tabs		✓	✓	✓	✓	✓

NOTES
Key: apo B = apolipoprotein B; TG = triglycerides; total-C = total cholesterol; LDL-C = low-density lipoproteins; CVD = cardiovascular disease; IDL = intermediate-density lipoproteins; VLDL = very low density lipoproteins; HDL-C = high-density lipoproteins ¹ Reduction in risk of coronary artery disease when first line agent is inadequate ² To reduce elevated sitosterol and campesterol in homozygous familial sitosterolemia ³ Also to reduce elevated non-HDL-C (total-C minus HDL-C) ⁴ To reduce risk of: MI, stroke, or coronary revascularization procedures, and morbidity/mortality. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Listed indications may be adjuncts to other therapies, lifestyle changes and/or concomitant drugs. (Rev. 9/2023)

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