Oral Acne Treatments- MPR

Oral Acne Treatments

ORAL ACNE TREATMENTS
Generic	Brand	Strength	Form	Dose
ANTIBIOTICS
doxycycline	—	50mg, 75mg, 100mg	caps	Adults: 200mg for 1 day (100mg every 12hrs or 50mg every 6hrs), then 100mg daily (as a single dose or 50mg every 12hrs) Children: ≤8yrs: not usually recommended. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily in 1–2 divided doses; (≥45kg): use Adults dose
	—	100mg	tabs	Adults: 100mg every 12hrs for 1 day, then 100mg/day in 1−2 divided doses; reduce dose after improvement
	Acticlate	75mg, 150mg+	tabs⁶	Adults: 100mg every 12hrs, then 100mg daily (as a single dose or 50mg every 12hrs) Children ≤8yrs: not usually recommended. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily in 1–2 divided doses; (≥45kg): use Adults dose
	Doryx	50mg, 80mg, 200mg	del-rel tabs	Adults: 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs) Children ≤8yrs: not usually recommended. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily in 1–2 divided doses; (>45kg): use Adults dose
	Doryx MPC	60mg	del-rel tabs⁶	Adults: 120mg every 12hrs for 1 day, then 120mg daily (as a single dose or 60mg every 12hrs) Children: ≤8yrs: not usually recommended. >8yrs (<45kg): 5.3mg/kg in 2 divided doses for 1 day, then 2.6mg/kg daily in 1–2 divided doses; (≥45kg): use Adults dose
	Vibramycin	100mg	caps	Adults: 100mg every 12hrs for 1 day, then 100mg/day in 1−2 divided doses; reduce dose after improvement
		25mg/5mL	susp⁴
		50mg/5mL	syrup⁵
minocycline	—	50mg, 75mg, 100mg	caps	Adults: 200mg once then 100mg every 12hrs; or 100−200mg once then 50mg four times daily. Children ≤8yrs: not recommended. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12hrs
	Minocin	50mg, 100mg	pellet-filled caps
	Minolira	105mg, 135mg	ext-rel tabs	Adults: approx. 1mg/kg once daily for 12wks. Weight-based dosing (45–59kg): 52.5mg; (60–89kg): 67.5mg; (90–125kg): 105mg; (126–136kg): 135mg. Children: <12yrs: not established.
	Solodyn	55mg, 65mg, 80mg, 105mg, 115mg	ext-rel tabs	Adults: ≥12yrs: approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–49kg): 45mg; (50–59kg): 55mg; (60–71kg): 65mg; (72–84kg): 80mg; (85–96kg): 90mg; (97–110kg): 105mg; (111–125kg): 115mg; (126–136kg): 135mg
sarecycline	Seysara	60mg, 100mg, 150mg	tabs	Adults and Children: <9yrs: not recommended. ≥9yrs (33–54kg): 60mg once daily; (55–84kg): 100mg once daily; (85–136kg): 150mg once daily.
tetracycline	—	250mg, 500mg	caps	Adults: initially 1g daily in 2−4 divided doses. After improvement: 125−500mg daily. Children: Not recommended.
RETINOIDS
isotretinoin	Absorica	10mg, 20mg, 25mg*, 30mg, 35mg, 40mg	caps¹	Adults: 0.5−1mg/kg/day in 2 divided doses; treat for ≤15−20wks if nodule count reduced by >70%; max 2mg/kg/day. Repeat course only if necessary after ≥2mos drug-free interval. Children: <12yrs: not established.
	Amnesteem	10mg, 20mg, 40mg	caps¹
	Claravis	10mg, 20mg, 30mg, 40mg	caps^1,2
	Absorica LD	8mg, 16mg, 20mg, 24mg, 28mg, 32mg	hard gelatin caps¹	Adults: 0.4–0.8mg/kg/day in 2 divided doses; treat for 15–20wks or less if nodule count reduced by >70%; max 2mg/kg/day. Children: <12yrs: not established.
CONTRACEPTIVES
drospirenone/ ethinyl estradiol	Loryna	3mg/20mcg (24 tabs); inert (4 tabs)	tabs	Women ≥14yrs old: 1 tab daily for 28 days; repeat
drospirenone/ ethinyl estradiol	Yaz	3mg/20mcg (24 tabs); inert (4 tabs)	tabs	Women ≥14yrs old: 1 tab daily for 28 days; repeat
drospirenone/ ethinyl estradiol/ levomefolate calcium	Beyaz	3mg/20mcg/ 0.451mg (24 pink); levomefolate 0.451mg (4 light orange)	tabs	Women ≥14yrs old: 1 tab daily for 28 days; repeat
norethindrone acetate/ ethinyl estradiol	Tilia Fe	1mg/20mcg (5 tabs) + 1mg/30mcg (7 tabs) + 1mg/35mcg (9 tabs); inert (7 tabs); ferrous fumarate 75mg	tabs	Women ≥15yrs old: 1 tab daily for 28 days; repeat
norethindrone acetate/ ethinyl estradiol	Tri-Legest Fe		tabs	Women ≥15yrs old: 1 tab daily for 28 days; repeat
norgestimate/ ethinyl estradiol	Ortho Tri-Cyclen 28	0.18mg/35mcg (7 tabs) + 0.215mg/35mcg (7 tabs) + 0.25mg/35mcg (7 tabs); inert (7 tabs)	tabs	Women ≥15yrs old: 1 tab daily for 28 days; repeat
	Tri-Sprintec		tabs
	NOTES
Key: + = scored tablets; *contains tartrazine ¹contains soy; ²contains vitamin E; ³contains parabens; ⁴raspberry flavor; ⁵as calcium, raspberry-apple flavor; contains sulfites; ⁶contains sodium Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 12/2023)

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