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Viagra Generic Name & Formulations
Legal Class
Rx
General Description
Sildenafil citrate 25mg, 50mg, 100mg; tabs.
Pharmacological Class
Phosphodiesterase type 5 inhibitor (cGMP-specific).
How Supplied
Tabs 25mg—30; 50mg, 100mg—1, 30, 100
Manufacturer
Generic Availability
YES
Viagra Indications
Indications
Erectile dysfunction.
Viagra Dosage and Administration
Adult
Take 1 dose as needed about 1hr (½–4hrs) before sexual activity at frequency of up to once daily. Initially 50mg. May reduce dose to 25mg or increase to max of 100mg. Elderly, hepatic impairment, severe renal impairment, or concomitant strong CYP3A4 inhibitors: consider initial dose of 25mg. Concomitant ritonavir: max single sildenafil dose of 25mg in 48hrs. Concomitant α-blockers (patients should be stable on α-blocker therapy before starting): initially 25mg.
Children
Not established.
Viagra Contraindications
Contraindications
Concomitant organic nitrates or nitric oxide donors (eg, sodium nitroprusside). Concomitant guanylate cyclase (GC) stimulators (eg, riociguat).
Viagra Boxed Warnings
Not Applicable
Viagra Warnings/Precautions
Warnings/Precautions
Confirm diagnosis. Cardiovascular disease (eg, MI, stroke, or life-threatening arrhythmia within 6 months; BP<90/50 or >170/110; unstable angina, LV outflow obstruction, impaired autonomic regulation of BP). Anatomical penile deformation. Predisposition to priapism. History of non-arteritic anterior ischemic optic neuropathy (NAION) or those with "crowded" optic disc. Retinitis pigmentosa. Advise patients to discontinue if sudden vision or hearing loss occurs. Patients for whom sexual activity is inadvisable or contraindicated. Bleeding disorders. Active peptic ulcer.
Viagra Pharmacokinetics
See Literature
Viagra Interactions
Interactions
See Contraindications. Hypotension with nitrates, GC stimulators. Additive hypotensive effects with concomitant α-blockers (eg, doxazosin), antihypertensives (eg, amlodipine). Potentiated by CYP3A4 (eg, ketoconazole, itraconazole, erythromycin, saquinavir, ritonavir) or CYP2C9 inhibitors, or cimetidine. Antagonized by CYP3A4 inducers (eg, rifampin). Concomitant other erectile dysfunction treatments: not recommended.
Viagra Adverse Reactions
Adverse Reactions
Headache, flushing, dyspepsia, nasal congestion, back pain, myalgia, nausea, dizziness, rash, visual disturbances (eg, color tinge to vision, increased light sensitivity, blurred vision), sudden vision or hearing loss; rare: cardiovascular events, prolonged erection, priapism.
Viagra Clinical Trials
See Literature
Viagra Note
Not Applicable
Viagra Patient Counseling
See Literature
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