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Vesicare Ls Generic Name & Formulations
Legal Class
Rx
General Description
Solifenacin succinate 1mg/mL; oral susp; orange-flavor.
Pharmacological Class
Muscarinic antagonist.
See Also
How Supplied
Tabs—30, 90; Susp—150mL
Manufacturer
Generic Availability
NO
Vesicare Ls Indications
Indications
Treatment of neurogenic detrusor overactivity in pediatric patients.
Vesicare Ls Dosage and Administration
Adult
Not applicable.
Children
<2yrs: not established. Take once daily, followed by liquid (eg, water or milk). Base dose on body wt. ≥2yrs: 9–15kg: initially 2mL (max 4mL); >15–30kg: initially 3mL (max 5mL); >30–45kg: initially 3mL (max 6mL); >45–60kg: initially 4mL (max 8mL); >60kg: initially 5mL (max 10mL). Severe renal impairment (CrCl <30mL/min/1.73m2), moderate hepatic impairment (Child-Pugh B), or concomitant strong CYP3A4 inhibitors: do not exceed the recommended initial dose.
Vesicare Ls Contraindications
Contraindications
For tabs: urinary retention. For tabs & susp: gastric retention, uncontrolled narrow-angle glaucoma.
Vesicare Ls Boxed Warnings
Not Applicable
Vesicare Ls Warnings/Precautions
Warnings/Precautions
Significant bladder outlet obstruction, decreased GI motility, high risk or history of QT prolongation, severe hepatic impairment (Child-Pugh C): not recommended. Controlled narrow-angle glaucoma. Monitor for CNS effects esp. after initiation or dose increases; consider dose reduction or discontinuation if occurs. Severe renal or moderate hepatic impairment. Pregnancy. Nursing mothers.
Vesicare Ls Pharmacokinetics
See Literature
Vesicare Ls Interactions
Interactions
Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). May be antagonized by CYP3A4 inducers. Avoid drugs known to prolong the QT interval. Additive anticholinergic effects with other anticholinergics.
Vesicare Ls Adverse Reactions
Adverse Reactions
Dry mouth, constipation, UTI, blurred vision; CNS effects (eg, headache, confusion, hallucination, somnolence); angioedema and anaphylactic reactions (discontinue if occurs).
Vesicare Ls Clinical Trials
See Literature
Vesicare Ls Note
Not Applicable
Vesicare Ls Patient Counseling
See Literature
