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Uroxatral Generic Name & Formulations
Legal Class
Rx
General Description
Alfuzosin (as HCl) 10mg; ext-rel tabs.
Pharmacological Class
Alpha-1 blocker.
How Supplied
Tabs—30, 100
Manufacturer
Uroxatral Indications
Indications
Benign prostatic hyperplasia (BPH).
Limitations of Use
Not for use in children or for the treatment of hypertension.
Uroxatral Dosage and Administration
Adult
Swallow whole. Take immediately after same meal each day. 10mg once daily.
Children
Not applicable.
Uroxatral Contraindications
Contraindications
Concomitant potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir). Moderate or severe hepatic impairment.
Uroxatral Boxed Warnings
Not Applicable
Uroxatral Warnings/Precautions
Warnings/Precautions
Not for use in women. Discontinue if angina develops or worsens. Severe renal insufficiency (CrCl <30mL/min). Hypotension. Mild hepatic impairment. History of QT interval prolongation. Exclude prostate cancer prior to initiation. Cataract surgery (intraoperative floppy iris syndrome possible).
Uroxatral Pharmacokinetics
See Literature
Uroxatral Interactions
Interactions
See Contraindications. Do not use with other α-blockers. Increased hypotension with concomitant nitrates, PDE5 inhibitors, other antihypertensives. Potentiates and is potentiated by cimetidine. Potentiates cardiovascular effects of atenolol. Caution with drugs that prolong QT interval.
Uroxatral Adverse Reactions
Adverse Reactions
Dizziness, upper respiratory tract infection, headache, fatigue; postural hypotension, syncope; rare: priapism.
Uroxatral Clinical Trials
See Literature
Uroxatral Note
Not Applicable
Uroxatral Patient Counseling
See Literature
