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Myrbetriq Generic Name & Formulations
Legal Class
Rx
General Description
Mirabegron 25mg, 50mg; ext-rel tabs.
Pharmacological Class
Beta-3 adrenergic agonist.
See Also
How Supplied
Tabs—30, 90; Granules—1
Manufacturer
Generic Availability
NO
Myrbetriq Indications
Indications
Overactive bladder (OAB) in adults with symptoms of urge urinary incontinence, urgency, and urinary frequency, as monotherapy or in combination with solifenacin. Neurogenic detrusor overactivity (NDO) in pediatric patients aged ≥3yrs and weighing ≥35kg.
Myrbetriq Dosage and Administration
Adult
Swallow tabs whole with water. Initially 25mg once daily; may increase to max 50mg once daily after 4–8 weeks if needed. Severe renal impairment or moderate hepatic impairment: max 25mg once daily. ESRD, requiring dialysis, or severe hepatic impairment: not recommended.
Children
<3yrs: not established. Swallow tabs whole with water. Take with food. ≥3yrs (≥35kg): Initially 25mg once daily; may increase to max 50mg once daily after 4–8 weeks if needed. Severe renal impairment or moderate hepatic impairment: max 25mg once daily. ESRD, requiring dialysis, or severe hepatic impairment: not recommended.
Myrbetriq Contraindications
Not Applicable
Myrbetriq Boxed Warnings
Not Applicable
Myrbetriq Warnings/Precautions
Warnings/Precautions
Do not substitute tabs and granules on a mg-per-mg basis. Severe uncontrolled hypertension: not recommended. Monitor blood pressure periodically. Significant bladder outlet obstruction, patients taking antimuscarinic drugs for OAB: risk of urinary retention. Discontinue and treat if angioedema of the tongue, hypopharynx, or larynx occurs. Pregnancy. Nursing mothers.
Myrbetriq Pharmacokinetics
See Literature
Myrbetriq Interactions
Interactions
May potentiate CYP2D6 substrates (eg, metoprolol, desipramine); adjust dose and monitor esp. with narrow therapeutic index drugs (eg, thioridazine, flecainide, propafenone). Concomitant digoxin: use lowest digoxin dose initially (monitor and titrate).
Myrbetriq Adverse Reactions
Adverse Reactions
Adults: hypertension, nasopharyngitis, UTI, headache; also with solifenacin: dry mouth, constipation, tachycardia. Children: UTI, nasopharyngitis, constipation, headache.
Myrbetriq Clinical Trials
See Literature
Myrbetriq Note
Not Applicable
Myrbetriq Patient Counseling
See Literature
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