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Muse Generic Name & Formulations
Legal Class
Rx
General Description
Alprostadil 250mcg, 500mcg, 1000mcg; urethral suppository.
Pharmacological Class
Prostaglandin.
How Supplied
Urethral supps—6
Manufacturer
Mechanism of Action
Alprostadil (PGE1) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. The vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arterial inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through subtunical vessels is impeded and penile rigidity develops. This process is referred to as the corporal veno-occlusive mechanism.
Muse Indications
Indications
Erectile dysfunction.
Muse Dosage and Administration
Adult
Supervise titration. Initially 125–250mcg inserted in urethra after urination; adjust dose in stepwise manner on separate occasions; max 2 supps/day.
Children
Not recommended.
Muse Contraindications
Contraindications
Urethral stricture. Balanitis. Severe hypospadias and curvature. Acute or chronic urethritis. Predisposition to venous thrombosis (eg, sickle cell anemia or trait). Hyperviscosity syndrome. Patients for whom sexual activity is inadvisable or contraindicated. If partner is pregnant, use condom; if partner is of childbearing age, use contraception.
Muse Boxed Warnings
Not Applicable
Muse Warnings/Precautions
Warnings/Precautions
Exclude reversible causes. Hypotension. Bleeding disorders. Priapism. Pregnancy (Cat.C): see Contraindications.
Muse Pharmacokinetics
Elimination
Renal. Half-life: 0.5–10 minutes.
Muse Interactions
Interactions
Effect attenuated by drugs that interfere with erectile function (eg, decongestants). Caution with anticoagulants.
Muse Adverse Reactions
Adverse Reactions
Penile, urethral, or testicular pain, urethral burning, minor urethral bleeding/spotting, dizziness, hypotension, flu symptoms, rhinitis, others. Infrequent: priapism. Partners: vaginal burning/itching.
Muse Clinical Trials
See Literature
Muse Note
Not Applicable
Muse Patient Counseling
See Literature
