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Korsuva Generic Name & Formulations
Legal Class
Rx
General Description
Difelikefalin 65mcg/1.3mL (50mcg/mL); soln for IV inj; preservative-free.
Pharmacological Class
Opioid agonist.
How Supplied
Single-dose vial—1, 12
Manufacturer
Generic Availability
NO
Korsuva Indications
Indications
Moderate to severe pruritus associated with chronic kidney disease (CKD) in adults undergoing hemodialysis (HD).
Limitations of Use
Not recommended for patients on peritoneal dialysis.
Korsuva Dosage and Administration
Adult
Give 0.5mcg/kg by IV bolus inj into the venous line of dialysis circuit at the end of each HD treatment. Administer within 60mins after completion of the syringe prep.
Children
Not established.
Korsuva Contraindications
Not Applicable
Korsuva Boxed Warnings
Not Applicable
Korsuva Warnings/Precautions
Warnings/Precautions
May impair mental or physical abilities. Increased somnolence in ≥65yrs. Severe hepatic impairment: not recommended. Pregnancy. Nursing.
Korsuva Pharmacokinetics
See Literature
Korsuva Interactions
Interactions
Caution with concomitant centrally-acting depressant drugs, sedating antihistamines, opioid analgesics.
Korsuva Adverse Reactions
Adverse Reactions
Diarrhea, dizziness, nausea, gait disturbances, falls, hyperkalemia, headache, somnolence, mental status change.
Korsuva Clinical Trials
See Literature
Korsuva Note
Not Applicable
Korsuva Patient Counseling
See Literature
