Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Detrol La Generic Name & Formulations
Legal Class
Rx
General Description
Tolterodine tartrate 2mg, 4mg; ext-rel caps.
Pharmacological Class
Muscarinic antagonist.
See Also
How Supplied
LA—30, 90, 500; Tabs—60, 500
Manufacturer
Generic Availability
YES
Detrol La Indications
Indications
Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.
Detrol La Dosage and Administration
Adult
Swallow whole. 4mg once daily; may decrease to 2mg once daily. Concomitant strong CYP3A4 inhibitors (eg, ketoconazole, clarithromycin, ritonavir), or severe renal or mild to moderate hepatic dysfunction: 2mg once daily. Severe hepatic impairment, CrCl<10mL/min: not recommended.
Children
Not established.
Detrol La Contraindications
Contraindications
Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.
Detrol La Boxed Warnings
Not Applicable
Detrol La Warnings/Precautions
Warnings/Precautions
Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.
Detrol La Pharmacokinetics
See Literature
Detrol La Interactions
Interactions
Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.
Detrol La Adverse Reactions
Adverse Reactions
Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.
Detrol La Clinical Trials
See Literature
Detrol La Note
Not Applicable
Detrol La Patient Counseling
See Literature
