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Detrol Generic Name & Formulations
Legal Class
Rx
General Description
Tolterodine tartrate 1mg, 2mg; tabs.
Pharmacological Class
Muscarinic antagonist.
See Also
How Supplied
LA—30, 90, 500; Tabs—60, 500
Manufacturer
Generic Availability
YES
Detrol Indications
Indications
Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.
Detrol Dosage and Administration
Adult
2mg twice daily; may decrease to 1mg twice daily. Concomitant strong CYP3A4 inhibitors (ketoconazole, itraconazole, miconazole, clarithromycin, erythromycin, cyclosporine, vinblastine), or significant renal or hepatic dysfunction: 1mg twice daily.
Children
Not established.
Detrol Contraindications
Contraindications
Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.
Detrol Boxed Warnings
Not Applicable
Detrol Warnings/Precautions
Warnings/Precautions
Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.
Detrol Pharmacokinetics
See Literature
Detrol Interactions
Interactions
Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.
Detrol Adverse Reactions
Adverse Reactions
Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.
Detrol Clinical Trials
See Literature
Detrol Note
Not Applicable
Detrol Patient Counseling
See Literature
