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Cardura Xl Generic Name & Formulations
Legal Class
Rx
General Description
Doxazosin (as mesylate) 4mg, 8mg; ext-rel tabs.
Pharmacological Class
Alpha-1 blocker.
How Supplied
Tabs—30
Manufacturer
Cardura Xl Indications
Indications
BPH.
Cardura Xl Dosage and Administration
Adult
Swallow whole. Take w. breakfast. Initially 4mg once daily; may titrate after 3–4 weeks to max 8mg/day. If therapy is stopped for several days, restart at 4mg once daily. Switching from Cardura to Cardura XL: initially 4mg once daily; do not take final evening dose of Cardura. Concomitant PDE-5 inhibitors: initiate at lowest dose.
Children
Not established.
Cardura Xl Contraindications
Not Applicable
Cardura Xl Boxed Warnings
Not Applicable
Cardura Xl Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment: not recommended. Mild or moderate hepatic impairment. Syncope. Symptomatic hypotension. Exclude prostate cancer. Severe GI narrowing. Coronary insufficiency; discontinue if angina pectoris appears or worsen. Cataract surgery (intraoperative floppy iris syndrome possible). Elderly. Pregnancy, nursing mothers: not indicated for females.
Cardura Xl Pharmacokinetics
See Literature
Cardura Xl Interactions
Interactions
Caution with strong CYP3A4 inhibitors (eg, atanazavir, clarithromycin, indinavir, ketoconazole, itraconazole, nefazodone, others). Additive hypotension with concomitant PDE-5 inhibitors.
Cardura Xl Adverse Reactions
Adverse Reactions
Headache, dizziness, asthenia, hypotension, dyspnea, postural hypotension, somnolence, respiratory or urinary tract infections; rare: priapism.
Cardura Xl Clinical Trials
See Literature
Cardura Xl Note
Not Applicable
Cardura Xl Patient Counseling
See Literature
