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Calcitriol Injection Generic Name & Formulations
Legal Class
Rx
General Description
Calcitriol 1mcg/mL; soln for IV inj.
Pharmacological Class
Vit. D analog.
How Supplied
Contact supplier.
Manufacturer
Calcitriol Injection Indications
Indications
Hypocalcemia in patients on chronic renal dialysis. Secondary hyperparathyroidism.
Calcitriol Injection Dosage and Administration
Adult
≥13yrs: Initially 1–2mcg (0.02mcg/kg) 3 times weekly (approx. every other day); usual range: 0.5–4mcg 3 times weekly. May increase by 0.5–1mcg at 2–4 week intervals. Adjust dose based on PTH levels: see full labeling.
Children
<13yrs: not recommended.
Calcitriol Injection Contraindications
Contraindications
Hypercalcemia. Vit. D toxicity.
Calcitriol Injection Boxed Warnings
Not Applicable
Calcitriol Injection Warnings/Precautions
Warnings/Precautions
Avoid concurrent Vit. D therapy. Maintain adequate calcium intake. Keep serum calcium times phosphate (Ca x P) product below 70. Monitor serum calcium and phosphorus twice weekly at start of therapy, and during dose adjustment. Monitor magnesium, alkaline phosphatase, parathyroid hormone levels (PTH) periodically; if PTH levels fall <1.5–3xULN, reduce calcitriol dose or discontinue. Pregnancy (Cat.C). Nursing mothers: not recommended.
Calcitriol Injection Pharmacokinetics
See Literature
Calcitriol Injection Interactions
Interactions
Hypermagnesemia with magnesium-containing antacids. Arrhythmias with digitalis if hypercalcemia occurs.
Calcitriol Injection Adverse Reactions
Adverse Reactions
Symptoms of hypervitaminosis D, hypercalcemia, hypercalciuria, hyperphosphatemia.
Calcitriol Injection Clinical Trials
See Literature
Calcitriol Injection Note
Notes
Formerly known under the brand name Calcijex.
Calcitriol Injection Patient Counseling
See Literature
