Xhance Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Fluticasone propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. The precise mechanism through which fluticasone propionate affects nasal polyps and associated inflammatory symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (eg, mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (eg, histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation.
Xhance Indications
Indications
Chronic rhinosinusitis with or without nasal polyps.
Xhance Dosage and Administration
Adult
≥18yrs: 1 or 2 sprays in each nostril twice daily. Max total daily dose: 2 sprays in each nostril twice daily (744mcg/day).
Children
Administration
Xhance Contraindications
Not Applicable
Xhance Boxed Warnings
Not Applicable
Xhance Warnings/Precautions
Warnings/Precautions
Maintain regular regimen. Do not exceed recommended dose. Respiratory tract tuberculosis. Systemic infections. Ocular herpes simplex. Immunosuppression. If exposed to measles or chickenpox, consider anti-infective prophylactic therapy. If adrenal insufficiency exists following systemic corticosteroid therapy, replacement with topical corticosteroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude, depression). Recent nasal ulceration, surgery, trauma; avoid until healing has occurred. Change in vision, history of increased intraocular pressure, glaucoma, and/or cataracts: monitor closely; consider referral to an ophthalmologist if ocular symptoms develop or long-term use of Xhance. Monitor for hypercorticism and HPA axis suppression (if occur discontinue gradually), and candida infection or other nasal mucosal changes. Discontinue if septal perforation occurs. Discontinue if hypersensitivity reactions occur. Prolonged immobilization, family history of osteoporosis, postmenopausal, tobacco use, advanced age, poor nutrition: monitor bone mineral density. Hepatic impairment: monitor. Pregnancy. Nursing mothers.
Xhance Pharmacokinetics
Distribution
Volume of distribution: 4.2 L/kg. Human plasma protein bound at ~99%.
Elimination
Fecal, renal (<5%). Half-life: ~7.8 hours.
Xhance Interactions
Interactions
Xhance Adverse Reactions
Adverse Reactions
Xhance Clinical Trials
See Literature
Xhance Note
Not Applicable
Xhance Patient Counseling
See Literature