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Theo-24 Generic Name & Formulations
Legal Class
Rx
General Description
Theophylline 100mg, 200mg, 300mg, 400mg; ext-rel caps.
Pharmacological Class
Xanthine.
How Supplied
Caps 100mg, 400mg—100; 200mg, 300mg—100, 500
Manufacturer
Theo-24 Indications
Indications
Asthma. Chronic bronchitis. Emphysema.
Theo-24 Dosage and Administration
Adult
See literature. Swallow whole. Stabilized patients may be switched from immediate-release or controlled-release product to once- or twice-daily dosing with Theo-24 on a mg/mg basis. Do not take within 1 hour of fatty food if on high dose. Max without serum level monitoring: 12–15years: 16mg/kg (max 400mg) per day; ≥16years: 400mg/day.
Children
Not recommended.
Theo-24 Contraindications
Not Applicable
Theo-24 Boxed Warnings
Not Applicable
Theo-24 Warnings/Precautions
Warnings/Precautions
Not for primary treatment of acute attack. Active peptic ulcer. Arrhythmias. Seizure disorders. Hepatic dysfunction. CHF. Acute pulmonary edema. Cor pulmonale. Hypothyroidism. Fever. Sepsis. Shock. Monitor serum levels; do not try to maintain non-tolerated doses. Rapid metabolizers. Infants (<3 months of age) with reduced renal function. Neonates. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Theo-24 Pharmacokinetics
See Literature
Theo-24 Interactions
Interactions
See literature. Smokers have increased metabolism. Potentiated by quinolones, macrolides, enoxacin, cimetidine, alcohol, allopurinol, estrogen oral contraceptives, tacrine, interferon alpha, disulfiram, fluvoxamine, verapamil, mexiletine, methotrexate, pentoxifylline, propafenone, ticlopidine, thiabenazole. Antagonized by phenytoin, rifampin, barbiturates, carbamazepine, aminogluthethimide, moricizine, St. John's wort, isoproterenol, sulfinpyrazone. Avoid β-blockers. Antagonizes lithium, benzodiazepines, pancuronium, adenosine. Toxicity with sympathomimetics. Seizures with ketamine. Arrhythmias with halothane.
Theo-24 Adverse Reactions
Adverse Reactions
GI upset, headache, CNS stimulation, diuresis, arrhythmias, seizures.
Theo-24 Clinical Trials
See Literature
Theo-24 Note
Not Applicable
Theo-24 Patient Counseling
See Literature
