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Stiolto Respimat Generic Name & Formulations
Legal Class
Rx
General Description
Tiotropium 2.5mcg, olodaterol 2.5mcg; per actuation; inhalation spray; contains benzalkonium chloride.
Pharmacological Class
Anticholinergic + long-acting beta-2 agonist (LABA).
How Supplied
Inhaler (w. cartridge)—4g (60 inh)
Manufacturer
Generic Availability
NO
Stiolto Respimat Indications
Indications
Long-term maintenance treatment of COPD, including chronic bronchitis and/or emphysema.
Limitations of Use
Not indicated to treat acute deteriorations of COPD or for treatment of asthma.
Stiolto Respimat Dosage and Administration
Adult
Take at same time each day. 2 inhalations once daily; max 2 inhalations/24hrs.
Children
Not established.
Stiolto Respimat Contraindications
Contraindications
Use of LABA without inhaled corticosteroid (ICS) in asthma.
Stiolto Respimat Boxed Warnings
Not Applicable
Stiolto Respimat Warnings/Precautions
Warnings/Precautions
LABA as monotherapy (without ICS) for asthma can increase risk of asthma-related events. Do not initiate in acute deteriorating COPD. Not for relief of acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue if paradoxical bronchospasm or hypersensitivity reactions occur; use alternative therapy. Cardiovascular disease (esp. coronary insufficiency, arrhythmias, hypertrophic obstructive cardiomyopathy, hypertension). Convulsive disorders. Thyrotoxicosis. Prolongation of the QT interval. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Narrow-angle glaucoma. Monitor for signs/symptoms of prostatic hyperplasia, GI or GU obstruction. Risk of hypokalemia or hyperglycemia. Moderate to severe renal impairment: monitor for anticholinergic effects. Severe hepatic impairment. Pregnancy. Labor & delivery. Nursing mothers.
Stiolto Respimat Pharmacokinetics
See Literature
Stiolto Respimat Interactions
Interactions
Avoid with other anticholinergics. Caution with concomitant other adrenergic drugs. Concomitant xanthine derivatives, steroids, diuretics may potentiate hypokalemia. Extreme caution with MAOIs, tricyclics, or drugs known to prolong QTc interval. Antagonized by β-blockers; if needed, consider cardioselective agents. Potentiated by strong CYP450 and P-gp inhibitors (eg, ketoconazole).
Stiolto Respimat Adverse Reactions
Adverse Reactions
Nasopharyngitis, cough, back pain; paradoxical bronchospasm, urinary retention, hypokalemia, hypersensitivity reactions.
Stiolto Respimat Clinical Trials
See Literature
Stiolto Respimat Note
Not Applicable
Stiolto Respimat Patient Counseling
See Literature
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