Elixophyllin

Individualize. Calculate based on ideal body weight. <1yr: premature neonates: <24 days: 1mg/kg every 12hrs; ≥24 days: 1.5mg/kg every 12hrs. Full term infants and infants up to 52 weeks old: total dose (mg) = [(0.2 x age in weeks) + 5] x kg body weight; up to age 26 weeks, divide dose into 3 equal amounts given at 8hr intervals; >26 weeks, divide dose into 4 equal amounts given at 6hr intervals. Adjust to maintain peak steady state serum theophylline concentration of 5–10mcg/mL in neonates and 10–15mcg/mL in older infants. Children (1–15yrs) and adults (16–60yrs) without risk factors for impaired clearance: children<45kg: initially 12–14mg/kg/day up to max 300mg/day divided every 4–6hrs; after 3 days, if tolerated, increase dose to 16mg/kg/day up to max 400mg/day divided every 4–6hrs; after 3 more days, if tolerated, increase to 20mg/kg/day up to max 600mg/day divided every 4–6hrs. Children >45kg and adults: initially 300mg/day divided every 6–8hrs; after 3 days, if tolerated, increase to 400mg/day divided every 6–8hrs; after 3 more days, if tolerated, increase to 600mg/day divided every 6–8hrs. Patients with risk factors for impaired clearance, elderly, and in those whom it is not feasible to monitor theophylline concentrations: 1–15yrs: final dose not exceed 16mg/kg/day up to max 400mg/day; ≥16yrs: final dose not exceed 400mg/day. Loading dose for acute bronchodilation: a single 5mg/kg dose. Dose adjustments based on theophylline concentrations: see literature.