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Cafcit Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Caffeine citrate 20mg/mL (equivalent to caffeine base 10mg/mL); preservative-free.
Pharmacological Class
Xanthine.
See Also
How Supplied
Single-use vial (3mL)—1; Oral soln (3mL)—10
Manufacturer
Cafcit Oral Solution Indications
Indications
Short-term treatment of apnea of prematurity in infants 28 to <33 weeks gestational age.
Cafcit Oral Solution Dosage and Administration
Adult
Not applicable.
Children
Maintenance: 5mg/kg caffeine citrate orally every 24 hours. Adjust based on response and serum caffeine levels.
Cafcit Oral Solution Contraindications
Not Applicable
Cafcit Oral Solution Boxed Warnings
Not Applicable
Cafcit Oral Solution Warnings/Precautions
Warnings/Precautions
Measure baseline serum caffeine levels in infants previously treated with theophylline (or aminophylline) and in infants born to mothers who consumed caffeine prior to delivery. Serious toxicity may occur with serum caffeine levels >50mg/L. Exclude or treat other causes of apnea. Seizure disorders. Cardiovascular disease. Monitor caffeine levels in impaired renal or hepatic function; adjust dose to avoid toxicity. Monitor serum glucose levels and for necrotizing enterocolitis. Pregnancy (Cat.C).
Cafcit Oral Solution Pharmacokinetics
See Literature
Cafcit Oral Solution Interactions
Interactions
Avoid concomitant theophylline, aminophylline (increased toxicity). May be potentiated by cimetidine, ketoconazole, others (may need to reduce caffeine dose). May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.
Cafcit Oral Solution Adverse Reactions
Adverse Reactions
CNS stimulation, cardiovascular or GI effects, increased gastric aspirate, feeding intolerance, hypo- or hyperglycemia, hemorrhage, acidosis, sepsis, lung edema, dyspnea, renal effects (eg, diuresis, renal failure), necrotizing enterocolitis.
Cafcit Oral Solution Clinical Trials
See Literature
Cafcit Oral Solution Note
Not Applicable
Cafcit Oral Solution Patient Counseling
See Literature
