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Cafcit Injection Generic Name & Formulations
Legal Class
Rx
General Description
Caffeine citrate 20mg/mL (equivalent to caffeine base 10mg/mL); soln for IV infusion; preservative-free.
Pharmacological Class
Xanthine.
See Also
How Supplied
Single-use vial (3mL)—1; Oral soln (3mL)—10
Manufacturer
Cafcit Injection Indications
Indications
Short-term treatment of apnea of prematurity in infants 28 to <33 weeks gestational age.
Cafcit Injection Dosage and Administration
Adult
Not applicable.
Children
Use a syringe infusion pump when infusing. Loading dose: 20mg/kg caffeine citrate by IV infusion once (over 30 minutes); then, beginning 24 hours after loading dose: maintenance 5mg/kg caffeine citrate by IV infusion every 24 hours (over 10 minutes). Adjust based on response and serum caffeine levels.
Cafcit Injection Contraindications
Not Applicable
Cafcit Injection Boxed Warnings
Not Applicable
Cafcit Injection Warnings/Precautions
Warnings/Precautions
Measure baseline serum caffeine levels in infants previously treated with theophylline (or aminophylline) and in infants born to mothers who consumed caffeine prior to delivery. Serious toxicity may occur with serum caffeine levels >50mg/L. Exclude or treat other causes of apnea. Seizure disorders. Cardiovascular disease. Monitor caffeine levels in impaired renal or hepatic function; adjust dose to avoid toxicity. Monitor serum glucose levels and for necrotizing enterocolitis. Pregnancy (Cat.C).
Cafcit Injection Pharmacokinetics
See Literature
Cafcit Injection Interactions
Interactions
Avoid concomitant theophylline, aminophylline (increased toxicity). May be potentiated by cimetidine, ketoconazole, others (may need to reduce caffeine dose). May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.
Cafcit Injection Adverse Reactions
Adverse Reactions
CNS stimulation, cardiovascular or GI effects, increased gastric aspirate, feeding intolerance, hypo- or hyperglycemia, hemorrhage, acidosis, sepsis, lung edema, dyspnea, renal effects (eg, diuresis, renal failure), necrotizing enterocolitis.
Cafcit Injection Clinical Trials
See Literature
Cafcit Injection Note
Not Applicable
Cafcit Injection Patient Counseling
See Literature
