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Bronchitol Generic Name & Formulations
Legal Class
Rx
General Description
Mannitol 40mg; per cap; pwd for oral inhalation; with inhaler.
Pharmacological Class
Sugar alcohol.
How Supplied
Caps—10, 140, 560 (w. inhalers)
Manufacturer
Generic Availability
NO
Bronchitol Indications
Indications
As add-on maintenance therapy to improve pulmonary function in adults with cystic fibrosis. Use only in those who have passed the Bronchitol Tolerance Test (BTT).
Bronchitol Dosage and Administration
Adult
Must perform the BTT and evaluate response prior to prescribing. Administer an orally inhaled, short-acting bronchodilator 5–15mins prior to each dose. 400mg twice daily by oral inhalation (contents of 10 caps administered individually) via the inhaler. Take in the AM and PM (with the later dose at least 2–3hrs before bedtime). Discard inhaler and replace after 7 days of use.
Children
Not established.
Bronchitol Contraindications
Contraindications
Failure to pass the Bronchitol Tolerance Test (BTT).
Bronchitol Boxed Warnings
Not Applicable
Bronchitol Warnings/Precautions
Warnings/Precautions
Must be administered under the supervision of a healthcare provider. Have rescue medication and resuscitation equipment readily available. Discontinue immediately if bronchospasm occurs; treat with an inhaled short-acting bronchodilator or as appropriate. History of significant hemoptysis episodes (>60mL) in the previous 3 months: not studied. Renal impairment. Pregnancy. Nursing mothers.
Bronchitol Pharmacokinetics
See Literature
Bronchitol Interactions
Not Applicable
Bronchitol Adverse Reactions
Adverse Reactions
Cough, hemoptysis (discontinue if occurs), oropharyngeal pain, vomiting, bacteria sputum identified, pyrexia, arthralgia; bronchospasm.
Bronchitol Clinical Trials
See Literature
Bronchitol Note
Not Applicable
Bronchitol Patient Counseling
See Literature
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