Xywav

IH: not established. Narcolepsy: <7yrs: not established. Take on empty stomach. Dilute each dose with 60mL of water. ≥7yrs (<20kg): see full labeling. (20–<30kg): initially ≤2g/night in two equally divided doses, at bedtime then again 2.5–4hrs later. May increase by 1g/night (0.5g/dose) at weekly intervals. Max total dose: 6g/night. (30–<45kg): initially ≤3g/night in two equally divided doses, at bedtime then again 2.5–4hrs later. May increase by 1g/night (0.5g/dose) at weekly intervals. Max total dose: 7.5g/night. (≥45kg): initially ≤4.5g/night in two equally divided doses, at bedtime then again 2.5–4hrs later. May increase by 1.5g/night (0.75g/dose) at weekly intervals. Max total dose: 9g/night. Some patients may respond better with unequal doses. Allow 6hrs before becoming active after last dose. Consider concomitant CNS stimulant use (see full labeling). Transitioning from Xyrem: initiate at same dose (gram for gram) and regimen; titrate as needed. Hepatic impairment: initially 1⁄2 of original dose per night, given in two equally divided doses. Concomitant divalproex sodium: reduce initial Xywav dose by at least 20%; if already taking divalproex sodium, start Xywav at lower dose; monitor, adjust accordingly.