Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Trifluoperazine Generic Name & Formulations
Legal Class
Rx
General Description
Trifluoperazine (as HCl) 1mg, 2mg, 5mg, 10mg; tabs.
Pharmacological Class
Phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Trifluoperazine Indications
Indications
Short-term (up to 12 weeks) treatment of nonpsychotic anxiety.
Trifluoperazine Dosage and Administration
Adult
1–2mg twice daily; max 6mg/day.
Children
Not recommended.
Trifluoperazine Contraindications
Contraindications
Coma. CNS or bone marrow depression. Blood dyscrasias. Liver disease.
Trifluoperazine Boxed Warnings
Not Applicable
Trifluoperazine Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to at least 24 hrs after myelography. Cardiovascular disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Mental retardation. Elderly. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy, nursing mothers: not recommended.
Trifluoperazine Pharmacokinetics
See Literature
Trifluoperazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Potentiates phenytoin, propranolol, α-blockers. May be potentiated by propranolol. Antagonizes guanethidine, oral anticoagulants. Antagonized by anticholinergics. Orthostatic hypotension with thiazides. May cause false (+) PKU test. Adjust antiepileptic drugs.
Trifluoperazine Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, blood dyscrasias, jaundice, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, anticholinergic effects, insomnia, extrapyramidal reactions, agitation, photosensitivity, neuroleptic malignant syndrome.
Trifluoperazine Clinical Trials
See Literature
Trifluoperazine Note
Notes
Formerly known under the brand name Stelazine.
Trifluoperazine Patient Counseling
See Literature
Trifluoperazine Generic Name & Formulations
Legal Class
Rx
General Description
Trifluoperazine (as HCl) 1mg, 2mg, 5mg, 10mg; tabs.
Pharmacological Class
Piperazine phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Trifluoperazine Indications
Indications
Psychosis.
Trifluoperazine Dosage and Administration
Adult
Initially: 2–5mg twice daily. Usual range: 15–20mg/day.
Children
<6yrs: not recommended. ≥6yrs (under close supervision): initially 1mg 1–2 times a day. Usual max 15mg/day.
Trifluoperazine Contraindications
Contraindications
Coma. CNS or bone marrow depression. Blood dyscrasias. Liver disease.
Trifluoperazine Boxed Warnings
Not Applicable
Trifluoperazine Warnings/Precautions
Warnings/Precautions
Discontinue at least 48 hrs before to at least 24 hrs after myelography. Cardiovascular disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and visual function. Mental retardation. Elderly. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy, nursing mothers: not recommended.
Trifluoperazine Pharmacokinetics
See Literature
Trifluoperazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Potentiates phenytoin, propranolol, α-blockers. May be potentiated by propranolol. Antagonizes guanethidine, oral anticoagulants. Antagonized by anticholinergics. Orthostatic hypotension with thiazides. May cause false (+) PKU test. Adjust antiepileptic drugs.
Trifluoperazine Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, blood dyscrasias, jaundice, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, anticholinergic effects, insomnia, extrapyramidal reactions, agitation, photosensitivity, neuroleptic malignant syndrome.
Trifluoperazine Clinical Trials
See Literature
Trifluoperazine Note
Not Applicable
Trifluoperazine Patient Counseling
See Literature
