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Thiothixene Generic Name & Formulations
Legal Class
Rx
General Description
Thiothixene 1mg, 2mg, 5mg, 10mg; caps.
Pharmacological Class
Thioxanthene.
How Supplied
Contact supplier.
Manufacturer
Thiothixene Indications
Indications
Schizophrenia.
Thiothixene Dosage and Administration
Adult
Individualize. Mild: initially 2mg three times daily, may subsequently increase to 15mg/day. Severe: initially 5mg twice daily. Usual optimal dose: 20–30mg daily; if needed, may increase to max 60mg/day.
Children
Not recommended.
Thiothixene Contraindications
Contraindications
Circulatory collapse. Coma. CNS depression. Blood dyscrasias.
Thiothixene Boxed Warnings
Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis.
Thiothixene Warnings/Precautions
Warnings/Precautions
Elderly with dementia-related psychosis (not approved use): increased risk of death. History of convulsive disorders or alcohol withdrawal. Exposure to extreme heat. Cardiovascular disease. Pre-existing low WBC or history of drug induced leukopenia/neutropenia; monitor CBCs during 1st few months of treatment. If significant neutropenia occurs; monitor for fever and signs of infections; discontinue if ANC<1000/mm3. Hepatic impairment. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy.
Thiothixene Pharmacokinetics
See Literature
Thiothixene Interactions
Interactions
Additive effects with hypotensive agents, CNS depressants and alcohol. Potentiates barbiturates. Antagonized by carbamazepine. Caution with concomitant atropine or related drugs.
Thiothixene Adverse Reactions
Adverse Reactions
Tardive dyskinesia, hypotension, drowsiness, insomnia, jaundice, blood dyscrasias, may mask emetic signs of overdosage or disease, lowered seizure threshold, rash, photosensitivity, hyperprolactinemia, anticholinergic effects, pigmentary retinopathy, lenticular pigmentation, extrapyramidal reactions, neuroleptic malignant syndrome (monitor).
Thiothixene Clinical Trials
See Literature
Thiothixene Note
Not Applicable
Thiothixene Patient Counseling
See Literature
