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Thioridazine Generic Name & Formulations
Legal Class
Rx
General Description
Thioridazine HCl 10mg, 25mg, 50mg, 100mg; tabs.
Pharmacological Class
Piperidine phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Thioridazine Indications
Indications
Schizophrenia unresponsive to (preferably 2) other antipsychotic drugs.
Thioridazine Dosage and Administration
Adult
Initially 50–100mg three times daily; may increase gradually to max 800mg/day in 2–4 divided doses.
Children
Initially 0.5mg/kg per day in divided doses; may increase gradually to max 3mg/kg per day.
Thioridazine Contraindications
Contraindications
History of arrhythmias. Congenital long QT syndrome. QTc interval >450msec. Concomitant drugs that prolong QTc interval, CYP2D6 inhibitors (eg, fluoxetine within past 5 weeks, paroxetine), or others that inhibit thioridazine metabolism (eg, duloxetine, fluvoxamine, propranolol, pindolol). Reduced CYP2D6 activity. Coma. CNS or bone marrow depression. Severe hyper- or hypotensive heart disease.
Thioridazine Boxed Warnings
Not Applicable
Thioridazine Warnings/Precautions
Warnings/Precautions
Discontinue if QTc interval >500msec occurs. Obtain ECG and K+ levels at baseline, then periodically (esp. after changing dose). Evaluate cardiac function if syncope, dizziness, palpitations, or other symptoms of torsade de pointes occurs. Bradycardia. Hypokalemia (correct K+ before starting). History of breast cancer. Seizure disorders. Monitor blood, liver and visual function. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers.
Thioridazine Pharmacokinetics
See Literature
Thioridazine Interactions
Interactions
See Contraindications. QTc interval prolongation with CYP2D6 inhibitors (eg, fluoxetine, paroxetine) or inhibitors of thioridazine metabolism (eg, duloxetine, fluvoxamine, propranolol, pindolol). Potentiates CNS depression with alcohol, other CNS depressants. Potentiates atropine, organophosphate toxicity. Antagonizes quetiapine. May cause false (+) pregnancy test.
Thioridazine Adverse Reactions
Adverse Reactions
Drowsiness, other CNS effects, anticholinergic effects, QT prolongation, arrhythmias, hyperprolactinemia, amenorrhea, ejaculation inhibition, edema, tardive dyskinesia, neuroleptic malignant syndrome, blood dyscrasias, jaundice, gynecomastia, weight gain, pigmentary retinopathy, orthostatic hypotension, hyperpyrexia, paradoxical reaction.
Thioridazine Clinical Trials
See Literature
Thioridazine Note
Notes
Formerly known under the brand name Mellaril.
Thioridazine Patient Counseling
See Literature
