Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Sonata Generic Name & Formulations
Legal Class
CIV
General Description
Zaleplon 5mg, 10mg; caps; contains tartrazine.
Pharmacological Class
Pyrazolopyrimidine hypnotic.
How Supplied
Caps—100
Manufacturer
Generic Availability
YES
Sonata Indications
Indications
Short-term treatment of insomnia.
Sonata Dosage and Administration
Adult
Use lowest effective dose. Effects delayed if taken with or after a heavy/high-fat meal. Usually 10mg immediately prior to bedtime or after patient has gone to bed and experienced difficulty falling asleep (with at least 7–8hrs of sleep remaining); max 20mg. Mild to moderate hepatic impairment, concomitant cimetidine, or low weight patients: 5mg. Elderly, debilitated: 5mg; max 10mg.
Children
Not established.
Sonata Contraindications
Contraindications
Prior history of complex sleep behaviors with Sonata.
Sonata Boxed Warnings
Boxed Warning
Complex sleep behaviors.
Sonata Warnings/Precautions
Warnings/Precautions
Risk of complex sleep behaviors (eg, sleep-walking, sleep-driving, engaging in other activities while not fully awake); discontinue immediately if occur. Monitor for CNS depressant effects and next-day impairment. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function. Conditions that affect metabolism or hemodynamic response. Drug or alcohol abuse. Severe hepatic impairment: not recommended. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly (higher risk of falls). Debilitated. Pregnancy, nursing mothers: not recommended.
Sonata Pharmacokinetics
See Literature
Sonata Interactions
Interactions
Concomitant other sedative-hypnotics at bedtime or middle of the night: not recommended. Potentiates CNS depression with alcohol, other CNS depressants; adjust dose. May be potentiated by CYP3A4 inhibitors (eg, erythromycin, ketoconazole) and drugs that inhibit aldehyde oxidase (eg, cimetidine, possibly diphenhydramine). May be antagonized by promethazine, CYP3A4 inducers (eg, rifampin, phenytoin, carbamazepine, phenobarbital); consider alternatives.
Sonata Adverse Reactions
Adverse Reactions
Headache, GI upset, abdominal pain, dizziness, somnolence; abnormal thinking and behavioral changes; rare: anaphylaxis, angioedema (do not rechallenge).
Sonata Clinical Trials
See Literature
Sonata Note
Not Applicable
Sonata Patient Counseling
See Literature
