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Seconal Sodium Generic Name & Formulations
Legal Class
CII
General Description
Secobarbital sodium 50mg, 100mg; caps.
Pharmacological Class
Barbiturate.
How Supplied
Caps—100
Manufacturer
Seconal Sodium Indications
Indications
For use as a preanesthetic sedative.
Seconal Sodium Dosage and Administration
Adult
200–300mg 1–2 hours before surgery. Elderly, debilitated, hepatic or renal impairment: reduce dose.
Children
2–6mg/kg before surgery. Max 100mg.
Seconal Sodium Contraindications
Contraindications
Manifest or latent porphyria. Marked hepatic impairment. Respiratory disease in which dyspnea or obstruction evident.
Seconal Sodium Boxed Warnings
Not Applicable
Seconal Sodium Warnings/Precautions
Warnings/Precautions
Premonitory signs of hepatic coma: not recommended. Renal or hepatic impairment. Acute or chronic pain. Depression. Suicidal tendencies. Drug or alcohol abuse. Monitor hematopoietic, renal, hepatic systems with long-term therapy. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. D); may cause fetal damage. Nursing mothers.
Seconal Sodium Pharmacokinetics
See Literature
Seconal Sodium Interactions
Interactions
Avoid concomitant griseofulvin. May antagonize oral anticoagulants (eg, warfarin), corticosteroids (may require dosage adjustments), doxycycline (monitor), oral contraceptives (consider alternative contraceptive method). May be potentiated by sodium valproate, valproic acid, MAOIs. Additive CNS depressant effects with alcohol, other CNS depressants. Concomitant phenytoin: monitor blood levels frequently.
Seconal Sodium Adverse Reactions
Adverse Reactions
Somnolence, agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, sleep-driving, hallucination, insomnia, anxiety, dizziness, abnormal thinking, hypoventilation, apnea, bradycardia, hypotension, syncope, GI upset, constipation, headache, hypersensitivity reactions, fever, liver damage.
Seconal Sodium Clinical Trials
See Literature
Seconal Sodium Note
Not Applicable
Seconal Sodium Patient Counseling
See Literature
Seconal Sodium Generic Name & Formulations
Legal Class
CII
General Description
Secobarbital sodium 50mg, 100mg; caps.
Pharmacological Class
Barbiturate.
How Supplied
Caps—100
Manufacturer
Seconal Sodium Indications
Indications
For short-term (2 weeks) treatment of insomnia.
Seconal Sodium Dosage and Administration
Adult
100mg at bedtime. Limit use to 2 weeks. Elderly, debilitated, hepatic or renal impairment: reduce dose.
Children
Not recommended.
Seconal Sodium Contraindications
Contraindications
Manifest or latent porphyria. Marked hepatic impairment. Respiratory disease in which dyspnea or obstruction evident.
Seconal Sodium Boxed Warnings
Not Applicable
Seconal Sodium Warnings/Precautions
Warnings/Precautions
Premonitory signs of hepatic coma: not recommended. Renal or hepatic impairment. Acute or chronic pain. Depression. Suicidal tendencies. Drug or alcohol abuse. Monitor hematopoietic, renal, hepatic systems with long-term therapy. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. D); may cause fetal damage. Nursing mothers.
Seconal Sodium Pharmacokinetics
See Literature
Seconal Sodium Interactions
Interactions
Avoid concomitant griseofulvin. May antagonize oral anticoagulants (eg, warfarin), corticosteroids (may require dosage adjustments), doxycycline (monitor), oral contraceptives (consider alternative contraceptive method). May be potentiated by sodium valproate, valproic acid, MAOIs. Additive CNS depressant effects with alcohol, other CNS depressants. Concomitant phenytoin: monitor blood levels frequently.
Seconal Sodium Adverse Reactions
Adverse Reactions
Somnolence, agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, sleep-driving, hallucination, insomnia, anxiety, dizziness, abnormal thinking, hypoventilation, apnea, bradycardia, hypotension, syncope, GI upset, constipation, headache, hypersensitivity reactions, fever, liver damage.
Seconal Sodium Clinical Trials
See Literature
Seconal Sodium Note
Not Applicable
Seconal Sodium Patient Counseling
See Literature
