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Pimozide Generic Name & Formulations
Legal Class
Rx
General Description
Pimozide 1mg, 2mg; scored tabs.
Pharmacological Class
Antipsychotic.
How Supplied
Contact supplier
Manufacturer
Pimozide Indications
Indications
Motor and phonic tics of Tourette's disorder unresponsive to standard treatment that severely compromise development or daily life function.
Pimozide Dosage and Administration
Adult
Initially 1–2mg/day in divided doses; may increase every other day to max 0.2mg/kg/day not to exceed 10mg/day.
Children
<12yrs: not recommended. ≥12yrs: Initially 0.05mg/kg once daily at bedtime; may increase every third day to max 0.2mg/kg, not to exceed 10mg/day.
Pimozide Contraindications
Contraindications
Simple tics or tics not associated with Tourette's disorder. Drugs that may cause tics (eg, pemoline, methylphenidate, amphetamines) or prolong the QT interval (eg, phenothiazines, tricyclic antidepressants, antiarrhythmics, dofetilide, sotalol, quinidine, other Class IA or III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, tacrolimus, ziprasidone, others). Congenital long QT syndrome. History of cardiac arrhythmias. Hypokalemia. Hypomagnesemia. Severe CNS depression or comatose states. Concomitant CYP3A4 inhibitors (eg, macrolides antibiotics, azole antifungals, protease inhibitors, nefazodone, zileuton, fluvoxamine, sertraline), citalopram, escitalopram.
Pimozide Boxed Warnings
Not Applicable
Pimozide Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. History of seizures or EEG abnormalities. Monitor ECG at baseline and periodically (esp. during dose adjustment). Correct hypokalemia before starting. Avoid abrupt cessation. May have tumorigenic potential. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy (Cat.C). Nursing mothers: not recommended.
Pimozide Pharmacokinetics
See Literature
Pimozide Interactions
Interactions
See Contraindications. May be potentiated by CYP1A2 inhibitors. Potentiates CNS depression with alcohol, analgesics, other CNS depressants. Caution with anticonvulsants. Avoid grapefruit juice.
Pimozide Adverse Reactions
Adverse Reactions
Sedation, anticholinergic effects, extrapyramidal symptoms, tardive dyskinesia, ECG changes, neuroleptic malignant syndrome, hyperpyrexia; leukopenia/neutropenia.
Pimozide Clinical Trials
See Literature
Pimozide Note
Notes
Formerly known under the brand name Orap.
Pimozide Patient Counseling
See Literature
