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Nortriptyline Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Nortriptyline (as HCl) 10mg/5mL; contains alcohol 4%.
Pharmacological Class
Tricyclic.
See Also
How Supplied
Caps—30; Soln—contact supplier
Manufacturer
Nortriptyline Oral Solution Indications
Indications
Depression.
Nortriptyline Oral Solution Dosage and Administration
Adult
Initially 25mg 3–4 times daily; max 150mg/day. Elderly and adolescents: 30–50mg/day in single or divided doses.
Children
Not recommended.
Nortriptyline Oral Solution Contraindications
Contraindications
During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.
Nortriptyline Oral Solution Boxed Warnings
Boxed Warning
Suicidality and antidepressant drugs.
Nortriptyline Oral Solution Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents and young adults; monitor for clinical worsening and unusual changes. Monitor for emergence of serotonin syndrome; discontinue if occurs. Mania/hypomania. Bipolar disorder. Psychosis. ECT. Cardiovascular disease. Avoid in Brugada syndrome. Angle-closure glaucoma. Urinary retention. Epilepsy. Hyperthyroidism. Diabetes. Liver disorders. Monitor plasma levels if dose >100mg/day. Elderly. Pregnancy. Nursing mothers.
Nortriptyline Oral Solution Pharmacokinetics
See Literature
Nortriptyline Oral Solution Interactions
Interactions
See Contraindications. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Potentiates alcohol, sympathomimetics. CNS stimulation with reserpine. Potentiated by CYP2D6 inhibitors; monitor plasma levels with quinidine, cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, propafenone, flecainide). Antagonized by barbiturates, carbamazepine. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine.
Nortriptyline Oral Solution Adverse Reactions
Adverse Reactions
Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice.
Nortriptyline Oral Solution Clinical Trials
See Literature
Nortriptyline Oral Solution Note
Not Applicable
Nortriptyline Oral Solution Patient Counseling
See Literature
