Nembutal

— THERAPEUTIC CATEGORIES —
  • Sleep-wake disorders
PAGE CONTENTS
  • Jump to Section
  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Nembutal Generic Name & Formulations

    Legal Class

    CII

    General Description

    Pentobarbital sodium 50mg/mL; soln for IM or IV inj; contains alcohol.

    Pharmacological Class

    Barbiturate.

    How Supplied

    Multi-dose vials (20mL, 50mL)—1

    Manufacturer

    Akorn, Inc.

    Nembutal Indications

    Indications

    Short-term (≤ 2 weeks) treatment of insomnia when oral route is not feasible.

    Nembutal Dosage and Administration

    Adult

    IM: 150mg–200mg (max 5mL/inj) as a single deep IM inj. IV: Inject slowly (max 50mg/min). ≥70kg: initially 100mg; observe and monitor vital signs at least 1 minute, then may increase as needed in small increments to usual max 500mg. Elderly, debilitated, renal or hepatic impairment: reduce dose.

    Children

    IM: 2–6mg/kg as a single deep IM inj; max 100mg. IV: inject slowly; reduce adult dose proportionally (see literature).

    Nembutal Contraindications

    Contraindications

    Porphyria.

    Nembutal Boxed Warnings

    Not Applicable

    Nembutal Warnings/Precautions

    Warnings/Precautions

    Prehepatic coma: not recommended. Avoid abrupt cessation. Acute or chronic pain. Depression. Suicidal tendencies. Drug abuser. Hepatic or renal impairment. Monitor BP, respiration, cardiac function. Avoid extravasation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D). Nursing mothers.

    Nembutal Pharmacokinetics

    See Literature

    Nembutal Interactions

    Interactions

    Potentiated by MAOIs, valproic acid, sodium valproate (monitor). CNS depression potentiated with alcohol, other CNS depressants. Antagonizes anticoagulants, corticosteroids, other steroid hormones (eg, oral contraceptives), doxycycline. May interfere with griseofulvin absorption. Variable effects with phenytoin (monitor).

    Nembutal Adverse Reactions

    Adverse Reactions

    Somnolence, respiratory depression, CNS effects, bradycardia, hypotension, syncope, GI upset, headache, inj site reactions, paradoxical excitement.

    Nembutal Clinical Trials

    See Literature

    Nembutal Note

    Not Applicable

    Nembutal Patient Counseling

    See Literature

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