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Nefazodone Generic Name & Formulations
Legal Class
Rx
General Description
Nefazodone HCl 50mg, 100mg+, 150mg+, 200mg, 250mg; tabs; +scored.
Pharmacological Class
Phenylpiperazine.
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
The mechanism of action of nefazodone, as with other antidepressants, is unknown. Preclinical studies have shown that nefazodone inhibits neuronal uptake of serotonin and norepinephrine.
Nefazodone Indications
Indications
Depression.
Nefazodone Dosage and Administration
Adult
≥18 years: initially 200mg daily in 2 divided doses; increase in increments of 100–200mg/day in 2 divided doses at 1-week intervals; range 300–600mg/day. Debilitated: initially 100mg daily in 2 divided doses.
Children
Not established.
Nefazodone Contraindications
Contraindications
Concomitant MAOIs, cisapride, carbamazepine; triazolam (see Interactions). Active liver disease. Elevated baseline serum transaminases. History of nefazodone-associated liver dysfunction.
Nefazodone Boxed Warnings
Not Applicable
Nefazodone Warnings/Precautions
Warnings/Precautions
Monitor for liver dysfunction; discontinue if signs of liver disease occur (eg, AST or ALT ≥ 3XULN). Cardio- or cerebrovascular disease. Predisposition to hypotension (eg, dehydration, hypovolemia). Mania/hypomania. Suicidal patients. Seizure disorders. Hepatic cirrhosis. Discontinue and reevaluate if priapism occurs. ECT. Reevaluate periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Nefazodone Pharmacokinetics
Elimination
Renal. Half-life: 2–4 hours.
Nefazodone Interactions
Interactions
Allow 14 days after discontinuing an MAOI before starting nefazodone; allow 7 days after discontinuing nefazodone before starting an MAOI. Avoid alcohol. Avoid concomitant triazolam (esp. in elderly); if used, reduce concomitant triazolam dose by 75%. Reduce concomitant alprazolam dose by 50%. Caution with antihypertensives, diuretics, other CNS-active drugs, oral anticoagulants, oral hypoglycemics, aspirin, other highly protein-bound drugs, drugs metabolized by CYP3A4. Risk of rhabdomyolysis with statins metabolized by CYP3A4 (eg, simvastatin, lovastatin, atorvastatin). May potentiate buspirone, haloperidol (reduce dose); cyclosporine, tacrolimus, digoxin (monitor). Discontinue before general anesthesia.
Nefazodone Adverse Reactions
Adverse Reactions
Headache, nausea, dizziness, insomnia, asthenia, agitation, somnolence, dry mouth, constipation, blurred or abnormal vision, confusion, postural hypotension, priapism, others; rare: hepatic failure.
Nefazodone Clinical Trials
See Literature
Nefazodone Note
Notes
Formerly known under the brand name Serzone.
Nefazodone Patient Counseling
See Literature
