Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Nardil Generic Name & Formulations
Legal Class
Rx
General Description
Phenelzine sulfate 15mg; tabs.
Pharmacological Class
MAOI.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Nardil Indications
Indications
Refractory depression.
Nardil Dosage and Administration
Adult
Initially 15mg three times daily. Increase if needed to max 90mg daily. Reduce dose as condition improves.
Children
<16 yrs: not recommended.
Nardil Contraindications
Contraindications
See Interactions. Pheochromocytoma. Cardiovascular, cerebrovascular, or liver disease. Hypertension. Chronic headache. To avoid potentially severe or fatal interactions, allow sufficient drug-free interval (see full labeling) between phenelzine and: sympathomimetics (eg, amphetamines, pseudoephedrine), tricyclic antidepressants (eg, amitriptyline), maprotiline, mirtazapine, SSRIs or other neurotransmitter reuptake inhibitors (eg, fluoxetine), CNS depressants (eg, alcohol, barbiturates, narcotics), antihistamines, antihypertensives (eg, guanethidine), anesthetics, bupropion, buspirone, carbamazepine, cyclobenzaprine, dibenzazepines, diuretics, dextromethorphan, dopamine, other MAOIs (eg, tranylcypromine, selegiline, furazolidone, isocarboxazid), levodopa, methyldopa, methylphenidate, tryptophan, phenylalanine, tryptophan-, dopamine-, tyrosine-, or tyramine-containing foods, excess caffeine or chocolate. Meperidine within three weeks of phenelzine.
Nardil Boxed Warnings
Boxed Warning
Suicidality and antidepressant drugs.
Nardil Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Screen for risk of bipolar disorder prior to initiation. Mania/hypomania. Psychosis. Epilepsy. Hyperthyroidism. Surgery. Discontinue if palpitations or headache occurs and 48 hrs before to 24 hrs after myelography. Avoid abrupt cessation. Hypotension. Monitor blood pressure and observe patient frequently. May mask anginal pain or aggravate anxiety or agitation. Elderly. Debilitated. Pregnancy. Nursing mothers.
Nardil Pharmacokinetics
See Literature
Nardil Interactions
Interactions
See Contraindications. Hypertensive crises with sympathomimetics, levodopa, and high-tyramine foods (including cheese, salami, chocolate, wine, beer, pickled herring, chicken livers, yeast extract, yogurt, broad beans, others). Caution with antidiabetic agents, antiparkinson agents, disulfiram. Potentiates CNS depressants, antihypertensives. Psychosis with dextromethorphan. Circulatory collapse, coma, death with meperidine. Do not start within 5 wks of fluoxetine, or 2 wks of sertraline, paroxetine, bupropion, citalopram, or 1 wk of venlafaxine discontinuance.
Nardil Adverse Reactions
Adverse Reactions
Orthostatic hypotension, headache, CNS overstimulation, jaundice, seizures, changes in blood sugar, anticholinergic effects, GI disorders, rash, weight gain, sexual disturbances.
Nardil Clinical Trials
See Literature
Nardil Note
Not Applicable
Nardil Patient Counseling
See Literature
