Methylin Oral Solution

— THERAPEUTIC CATEGORIES —
  • ADHD
  • Sleep-wake disorders

Methylin Oral Solution Generic Name & Formulations

General Description

Methylphenidate HCl 5mg/5mL, 10mg/5mL; grape flavor.

Pharmacological Class

CNS stimulant.

How Supplied

Tabs, ext-rel tabs, chew tabs—contact supplier; Oral soln—500mL

Manufacturer

Mechanism of Action

The mechanism of action of methylphenidate is not completely understood, but it presumably activates the brain stem arousal system and cortex to produce its stimulant effect. Methylphenidate is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space.

Methylin Oral Solution Indications

Indications

Attention deficit hyperactivity disorder.

Methylin Oral Solution Dosage and Administration

Adult

10–60mg daily in 2–3 divided doses preferably 30–45 mins before meals. Chew tabs: take with 8oz of water or other fluid.

Children

<6yrs: not established. ≥6yrs: initially 5mg twice a day before breakfast and lunch. Increase gradually by 5–10mg per week if needed; max 60mg daily.

Methylin Oral Solution Contraindications

Contraindications

During or within 14 days of MAOIs. 

Methylin Oral Solution Boxed Warnings

Boxed Warning

Abuse, misuse, and addiction.

Methylin Oral Solution Warnings/Precautions

Warnings/Precautions

High potential for abuse, misuse, and addiction; assess patient’s risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Seizure disorder. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Risk for acute angle closure glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Monitor BP, HR, growth in children. Reduce dose or discontinue if paradoxical aggravation of symptoms occur. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.

Methylin Oral Solution Pharmacokinetics

Elimination

Renal.

Methylin Oral Solution Interactions

Interactions

See Contraindications. Avoid alcohol. Hypertensive crisis with MAOIs. Caution with pressor agents. Antagonizes guanethidine. May potentiate coumarin anticoagulants, anticonvulsants (eg, phenobarbital, phenytoin, primidone), phenylbutazone, tricyclics, SSRIs. May antagonize antihypertensive drugs; monitor and adjust dose of antihypertensives as needed. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.

Methylin Oral Solution Adverse Reactions

Adverse Reactions

Insomnia, nervousness, CNS overstimulation, anorexia, weight loss, abdominal pain, nausea, dizziness, headache; priapism, hypertension, tachycardia, visual disturbances, glaucoma, motor/verbal tics.

Methylin Oral Solution Clinical Trials

See Literature

Methylin Oral Solution Note

Not Applicable

Methylin Oral Solution Patient Counseling

See Literature

Methylin Oral Solution Generic Name & Formulations

General Description

Methylphenidate HCl 5mg/5mL, 10mg/5mL; grape flavor.

Pharmacological Class

CNS stimulant.

How Supplied

Tabs, ext-rel tabs, chew tabs—contact supplier; Oral soln—500mL

Manufacturer

Mechanism of Action

The mechanism of action of methylphenidate is not completely understood, but it presumably activates the brain stem arousal system and cortex to produce its stimulant effect. Methylphenidate is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space.

Methylin Oral Solution Indications

Indications

Narcolepsy.

Methylin Oral Solution Dosage and Administration

Adult

10–60mg daily in 2–3 divided doses preferably 30–45 mins before meals. Chew tabs: take with 8oz of water or other fluid.

Children

<6yrs: not established. ≥6yrs: initially 5mg twice a day before breakfast and lunch. Increase gradually by 5–10mg per week if needed; max 60mg daily.

Methylin Oral Solution Contraindications

Contraindications

During or within 14 days of MAOIs. 

Methylin Oral Solution Boxed Warnings

Boxed Warning

Abuse, misuse, and addiction.

Methylin Oral Solution Warnings/Precautions

Warnings/Precautions

High potential for abuse, misuse, and addiction; assess patient’s risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Seizure disorder. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Risk for acute angle closure glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Monitor BP, HR, growth in children. Reduce dose or discontinue if paradoxical aggravation of symptoms occur. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.

Methylin Oral Solution Pharmacokinetics

Elimination

Renal.

Methylin Oral Solution Interactions

Interactions

See Contraindications. Avoid alcohol. Hypertensive crisis with MAOIs. Caution with pressor agents. Antagonizes guanethidine. May potentiate coumarin anticoagulants, anticonvulsants (eg, phenobarbital, phenytoin, primidone), phenylbutazone, tricyclics, SSRIs. May antagonize antihypertensive drugs; monitor and adjust dose of antihypertensives as needed. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.

Methylin Oral Solution Adverse Reactions

Adverse Reactions

Insomnia, nervousness, CNS overstimulation, anorexia, weight loss, abdominal pain, nausea, dizziness, headache; priapism, hypertension, tachycardia, visual disturbances, glaucoma, motor/verbal tics.

Methylin Oral Solution Clinical Trials

See Literature

Methylin Oral Solution Note

Not Applicable

Methylin Oral Solution Patient Counseling

See Literature