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Lunesta Generic Name & Formulations
Legal Class
CIV
General Description
Eszopiclone 1mg, 2mg, 3mg; tabs.
Pharmacological Class
Pyrrolopyrazine hypnotic.
How Supplied
Tabs 1mg—30; 2mg, 3mg—30, 100
Manufacturer
Generic Availability
YES
Lunesta Indications
Indications
Insomnia (decreased sleep latency and improved sleep maintenance).
Lunesta Dosage and Administration
Adult
Use lowest effective dose. Effects delayed if taken with or after a heavy/high-fat meal. ≥18yrs: initially 1mg immediately before bedtime (with at least 7–8hrs remaining before planned time of awakening); may increase to 2–3mg if needed; max 3mg/dose. Elderly, debilitated, concomitant CYP3A4 inhibitors, or severe hepatic impairment: max 2mg/dose.
Children
<18yrs: not established.
Lunesta Contraindications
Contraindications
Prior history of complex sleep behaviors with Lunesta.
Lunesta Boxed Warnings
Boxed Warning
Complex sleep behaviors.
Lunesta Warnings/Precautions
Warnings/Precautions
Risk of complex sleep behaviors (eg, sleep-walking, sleep-driving, engaging in other activities while not fully awake); discontinue immediately if occur. Monitor for CNS depressant effects and next-day impairment. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function. Conditions that affect metabolism or hemodynamic response. Drug or alcohol abuse. Hepatic impairment. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly (higher risk of falls). Debilitated. Pregnancy. Nursing mothers.
Lunesta Pharmacokinetics
See Literature
Lunesta Interactions
Interactions
Concomitant other sedative-hypnotics at bedtime or middle of the night: not recommended. Potentiates CNS depression with alcohol, other CNS depressants; adjust dose. Potentiated by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, troleandomycin, ritonavir, nelfinavir); see Adults. May be antagonized by CYP3A4 inducers (eg, rifampicin).
Lunesta Adverse Reactions
Adverse Reactions
Unpleasant taste, headache, somnolence, dizziness, dry mouth, infection, rash, anxiety, hallucinations; abnormal thinking and behavioral changes; rare: anaphylaxis, angioedema (do not rechallenge).
Lunesta Clinical Trials
See Literature
Lunesta Note
Not Applicable
Lunesta Patient Counseling
See Literature
