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Loxapine Generic Name & Formulations
Legal Class
Rx
General Description
Loxapine succinate 5mg, 10mg, 25mg, 50mg; caps.
Pharmacological Class
Dibenzoxazepine.
How Supplied
Contact supplier
Manufacturer
Loxapine Indications
Indications
Schizophrenia.
Loxapine Dosage and Administration
Adult
Individualize. Give in divided doses, usually 2–4 times daily. Initially 10mg twice daily; severe: initially up to a total of 50mg/day. Dosage may be increased over first 7 to 10 days until effective response; usual range 60–100mg daily. Max 250mg/day. Maintenance therapy: use lowest effective dose; range 20–60mg daily.
Children
Not established.
Loxapine Contraindications
Contraindications
Coma. Severe drug-induced (eg, alcohol, barbiturates, narcotics) depressed states.
Loxapine Boxed Warnings
Not Applicable
Loxapine Warnings/Precautions
Warnings/Precautions
Elderly (not for dementia-related psychosis; may increase risk of death). Management of behavioral complications in mental retardation patients: not recommended. History of convulsive disorders. Cardiovascular disease. Glaucoma. Urinary retention. Pre-existing low WBC or history of drug induced leukopenia/neutropenia; monitor CBCs during 1st few months of treatment. Monitor for fever and symptoms/signs of infection in patients with neutropenia; discontinue if severe (ANC<1000/mm3). Perform fall risk assessments when initiating and recurrently on long-term therapy. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: not recommended.
Loxapine Pharmacokinetics
See Literature
Loxapine Interactions
Interactions
Avoid concomitant alcohol, other CNS depressants. Caution with concomitant anticholinergic-type antiparkinson, CNS-active drugs. Significant respiratory depression, stupor and/or hypotension with lorazepam.
Loxapine Adverse Reactions
Adverse Reactions
Tardive dyskinesia, hypotension, drowsiness, insomnia, jaundice, blood dyscrasias, GI upset, may mask emetic signs of overdosage or disease, lowered seizure threshold, dermatitis, rash, hyperprolactinemia, anticholinergic effects, pigmentary retinopathy, lenticular pigmentation, extrapyramidal reactions, neuroleptic malignant syndrome (monitor).
Loxapine Clinical Trials
See Literature
Loxapine Note
Notes
Formerly known under the brand name Loxitane.
Loxapine Patient Counseling
See Literature
